Blood lipids and rheological modifications in glycogen storage disease
| Autor: | Alain Legrand, Jaime Levenson, Alain Simon, Jacqueline Chalas, Nicole Moatti, Seyed Mahmoud Razavian, Christiane Baussan, Karim Keddad, Annie Abella |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Erythrocyte Aggregation Male medicine.medical_specialty Adolescent Apolipoprotein B Lipoproteins Clinical Biochemistry Blood lipids Hyperlipidemias Erythrocyte aggregation Pathogenesis Internal medicine Hyperlipidemia medicine Humans Glycogen storage disease Child Apolipoproteins A Triglycerides Apolipoproteins B biology business.industry Hypertriglyceridemia Infant nutritional and metabolic diseases Blood Proteins General Medicine Glycogen Storage Disease medicine.disease Lipids Endocrinology Child Preschool Circulatory system biology.protein Female lipids (amino acids peptides and proteins) Rheology business |
| Zdroj: | Clinical Biochemistry. 29:73-78 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/0009-9120(95)02014-4 |
| Popis: | Objectives : Hyperlipidemia is a feature of liver glycogen storage disease (GSD). Recent studies have suggested that rheological mechanisms such as elevated erythrocyte aggregation may be involved in the pathogenesis of ischemic syndromes associated with hyperlipidemia. Design and Methods : We investigated erythrocyte aggregation, lipids, and circulatory proteins in the blood of 24 patients affected with GSD, aged from 1 to 23 years (mean = 8) and 26 controls aged from 1 to 28 years (mean = 9). Results : The aggregation results were much higher in patients than controls. The lipid data showed a mixed hyperlipidemia with predominent hypertriglyceridemia, low HDL-C, apoA-I and LpA-I/A-II, and high apoB as compared with controls. However, the LpA-I was not significantly different from controls. Conclusions : In conclusion, patients with GSD presented hyperlipidemia and elevated erythrocyte aggregation such that they are at long-term risk of ischemic complications. |
| Databáze: | OpenAIRE |
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