Implantation loss induced by ethanolamine in the rat is ameliorated by a choline-supplemented diet
| Autor: | Markus Wahl, Nigel P. Moore, Steffen Schneider |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Toxicology Choline Lesion 03 medical and health sciences chemistry.chemical_compound Ethanolamine Pregnancy Internal medicine medicine Animals Embryo Implantation Dosing Rats Wistar business.industry Embryo 030104 developmental biology Endocrinology chemistry Dietary Supplements Toxicity Gestation Female medicine.symptom business Homeostasis |
| Zdroj: | Reproductive Toxicology. 78:102-110 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2018.04.005 |
| Popis: | Ethanolamine (EA) reduced implantation success in a two-generation reproduction toxicity study; the aim of this work was to explore the underlying basis for this response. When administered to pregnant rats during gestation days (GD) 1-3, 4-5, or 6-7, EA had no effect upon implantation success. In a second experiment, EA was administered either in the diet or by oral gavage from two weeks prior to mating through to GD 8. Parallel groups also received a diet supplemented with choline. In the absence of supplementary choline, EA induced early resorptions, statistically significant only when administered in the diet. A slight reduction in implantation success was ameliorated by supplementary choline. We conclude that implantation is affected by EA only when exposure starts before mating; that dietary administration is more effective than gavage dosing; and that interference with choline homeostasis may play a role in the aetiology of this lesion. |
| Databáze: | OpenAIRE |
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