Dimethyl acetals, an indirect marker of the endogenous antioxidant plasmalogen level, are reduced in blood lipids of Sudanese pre-eclamptic subjects whose background diet is high in carbohydrate
| Autor: | Allain A. Bueno, Kebreab Ghebremeskel, Ishag Adam, Mustafa I. Elbashir, Khalid H. Bakheit |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Erythrocytes Antioxidant Plasmalogen medicine.medical_treatment Plasmalogens Blood lipids Oxidative phosphorylation medicine.disease_cause Antioxidants Sudan Acetals Pre-Eclampsia Pregnancy Internal medicine Dietary Carbohydrates Humans Medicine Triglycerides Red Cell business.industry Phosphatidylethanolamines Fatty Acids food and beverages Obstetrics and Gynecology Carbohydrate Diet Oxidative Stress Cholesterol Endocrinology Biochemistry Case-Control Studies Phosphatidylcholines Microsome Female lipids (amino acids peptides and proteins) business Biomarkers Oxidative stress |
| Zdroj: | Journal of Obstetrics and Gynaecology. 32:241-246 |
| ISSN: | 1364-6893 0144-3615 |
| DOI: | 10.3109/01443615.2011.641622 |
| Popis: | In Sudanese women with (n = 60) and without (n = 65) pre-eclampsia, circulating lipids, plasma and red cell saturated and monounsaturated fatty (MUFA) acids and dimethyl acetals (DMAs) were investigated. DMAs are an indirect marker of levels of plasmalogens, endogenous antioxidants, which play a critical role in oxidative protection, and cholesterol homeostasis. The pre-eclamptics had higher C18:1n-9 (p < 0.001) and ΣMUFA (p < 0.01) in plasma free fatty acids, C16:1n-7, C18:1n-9, ΣMUFA; 16:0/16:1n-7 (p < 0.01) in erythrocyte choline phosphoglycerides (ePC) and 16:1n-7, 18:1n-7 and 16:0/16:1n-7 (p < 0.01) in erythrocyte ethanolamine phosphoglycerides (ePE). In contrast, the DMAs 18:0, 18:1 and ΣDMAs in ePE, and 16:0, 18:0 and ΣDMAs in ePC were reduced (p < 0.001) in the pre-eclamptic women. This study of pregnant women with high carbohydrate and low fat background diet suggests pre-eclampsia is associated with oxidative stress and enhanced activity of the microsomal enzyme stearyl-CoA desaturase (delta 9 desaturase), as assessed by palmitic/palmitoleic (C16:0/C16:n-1) and stearic/oleic (C18/C18:1n-9) ratios. |
| Databáze: | OpenAIRE |
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