Lupus anticoagulant: interference with in vivo prostaglandin production and with platelet sensitivity to prostacyclin
| Autor: | Chiara Benedetto, G. Garis, Piercarla Schinco, Anna Maria Tavella, Giacomo Tamponi, Alessandra Borchiellini, Alessandro Pileri, D. Marranca, E. Melzi, Mario Bazzan, A. Fantino, V. Modena |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Immunology Prostaglandin Prostacyclin Pathogenesis chemistry.chemical_compound Thromboxane A2 Rheumatology In vivo Internal medicine medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Platelet Mixed Connective Tissue Disease Lupus anticoagulant Lupus erythematosus Scleroderma Systemic business.industry General Medicine Middle Aged medicine.disease Epoprostenol Endocrinology chemistry Lupus Coagulation Inhibitor cardiovascular system Prostaglandins lipids (amino acids peptides and proteins) Female business medicine.drug |
| Zdroj: | Scandinavian journal of rheumatology. 21(3) |
| ISSN: | 0300-9742 |
| Popis: | Schinco PC, Marranca D, Bazzan M, Borchiellini A, Fantino A, Garis G, Melzi E, Modena V, Tamponi G, Tavella AM, Pileri A, Benedetto C. Lupus Anticoagulant: Interference with In Vivo Prostaglandin Production and with Platelet Sensitivity to Prostacyclin. Scand J Rheumatol. 1992; 21: 124–28.The hypothesis has been made that inhibition of prostacyclin (PGI2) production may play a role in the pathogenesis of thrombosis in patients with the lupus anticoagulant (LA), but so far no evidence of reduced PGI2 levels in vivo has been produced. We have tested the plasma levels of PGI2 and thromboxane A2 (TXA2) and the platelet sensitivity to PGI2 in 14 patients with and without LA and in 14 healthy controls. No significant difference in the portioned basal levels was detected among the groups; however, in some patients PGI2 increments seemed to parallel the clinical course of the disease. Platelet sensitivity to exogenous PG12 was significantly enhanced in the LA + patients and correlated with PGU values. We suggest ... |
| Databáze: | OpenAIRE |
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