Impact of adjuvant treatment on outcome in high-risk early-stage endometrial cancer: a retrospective three-center study
| Autor: | Al Covens, Nasreen Hag-Yahia, Estela Derazne, Tamar Perri, Lilian T. Gien, Yfat Kadan, Sarit Kalfon, Natalie Lavee, Hila Amichay Chariski, Mario E. Beiner, Jacob Korach, Limor Helpman, Ami Fishman |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Gynecologic oncology Carcinosarcoma Internal medicine Adjuvant therapy Humans Medicine Prospective Studies Stage (cooking) Aged Neoplasm Staging Retrospective Studies Chemotherapy business.industry Proportional hazards model Endometrial cancer Obstetrics and Gynecology Chemoradiotherapy Adjuvant Middle Aged medicine.disease Cystadenocarcinoma Serous Endometrial Neoplasms Survival Rate Serous fluid Treatment Outcome Cohort Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | International Journal of Gynecologic Cancer. 29:133-139 |
| ISSN: | 1525-1438 1048-891X |
| Popis: | ObjectiveHigh grade and non-endometrioid endometrial cancers carry a poor prognosis, and the lack of randomized prospective data has led to a wide range of practice regarding adjuvant therapy. The objective of this study was to evaluate the outcomes of different treatment strategies in patients with high-risk, early-stage endometrial cancer.MethodsPatients with high-grade endometrioid, serous endometrial cancer and carcinosarcoma diagnosed between 2000 and 2012 were identified from databases in three gynecologic oncology divisions, in Toronto and in Israel. Adjuvant treatment practices differed across the centers, creating a heterogeneous cohort. A comparison of stage I patients stratified by adjuvant treatment was undertaken. Log-rank tests and Cox proportional hazards models were employed to compare recurrence and survival across treatment groups.Results490patients with high risk endometrial cancer were identified, among them 213 patients with stage I disease. Israeli patients received more chemotherapy (41% vs 10% in stage I disease; PConclusionsIn this retrospective analysis, neither adjuvant radiation nor chemotherapy were associated with improved outcome in stage I, high risk endometrial cancer. |
| Databáze: | OpenAIRE |
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