Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort
| Autor: | Frederike Cosima Oertel, Julia Krämer, Seyedamirhosein Motamedi, Azeen Keihani, Hanna G. Zimmermann, Nikolaos G. Dimitriou, Shivany Condor-Montes, Charlotte Bereuter, Christian Cordano, Ahmed Abdelhak, Anand Trip, Orhan Aktas, Sven G. Meuth, Heinz Wiendl, Klemens Ruprecht, Judith Bellmann-Strobl, Friedemann Paul, Axel Petzold, Alexander U. Brandt, Philipp Albrecht, Ari J. Green |
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| Přispěvatelé: | Neurology, Ophthalmology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Neuroinfection & -inflammation |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Retinal Ganglion Cells
Adult Male Multiple Sclerosis Optic Neuritis Neurosciences Middle Aged Neurodegenerative Prognosis Eye Autoimmune Disease Retina Brain Disorders Neurology Clinical Research Neurological Humans Female Neurology (clinical) Function and Dysfunction of the Nervous System Evoked Potentials Eye Disease and Disorders of Vision |
| Zdroj: | Neurology(R) neuroimmunology & neuroinflammation, vol 10, iss 3 Oertel, F C, Krämer, J, Motamedi, S, Keihani, A, Zimmermann, H G, Dimitriou, N G, Condor-Montes, S, Bereuter, C, Cordano, C, Abdelhak, A, Trip, A, Aktas, O, Meuth, S G, Wiendl, H, Ruprecht, K, Bellmann-Strobl, J, Paul, F, Petzold, A, Brandt, A U, Albrecht, P & Green, A J 2023, ' Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort ', Neurology(R) neuroimmunology & neuroinflammation, vol. 10, no. 3 . https://doi.org/10.1212/NXI.0000000000200092 Neurology(R) neuroimmunology & neuroinflammation, 10(3). Lippincott Williams and Wilkins |
| ISSN: | 2332-7812 |
| DOI: | 10.1212/NXI.0000000000200092 |
| Popis: | Background and ObjectivesWith the increasing use of visually evoked potentials (VEPs) as quantitative outcome parameters for myelin in clinical trials, an in-depth understanding of longitudinal VEP latency changes and their prognostic potential for subsequent neuronal loss will be required. In this longitudinal multicenter study, we evaluated the association and prognostic potential of VEP latency for retinal neurodegeneration, measured by optical coherence tomography (OCT), in relapsing-remitting MS (RRMS).MethodsWe included 293 eyes of 147 patients with RRMS (age [years, median ± SD] 36 ± 10, male sex 35%, F/U [years, median {IQR} 2.1 {1.5–3.9}]): 41 eyes had a history of optic neuritis (ON) ≥6 months before baseline (CHRONIC-ON), and 252 eyes had no history of ON (CHRONIC-NON). P100 latency (VEP), macular combined ganglion cell and inner plexiform layer volume (GCIPL), and peripapillary retinal nerve fiber layer thickness (pRNFL) (OCT) were quantified.ResultsP100 latency change over the first year predicted subsequent GCIPL loss (36 months) across the entire chronic cohort (p= 0.001) and in (and driven by) the CHRONIC-NON subset (p= 0.019) but not in the CHRONIC-ON subset (p= 0.680). P100 latency and pRNFL were correlated at baseline (CHRONIC-NONp= 0.004, CHRONIC-ONp< 0.001), but change in P100 latency and pRNFL were not correlated. P100 latency did not differ longitudinally between protocols or centers.DiscussionVEP in non-ON eyes seems to be a promising marker of demyelination in RRMS and of potential prognostic value for subsequent retinal ganglion cell loss. This study also provides evidence that VEP may be a useful and reliable biomarker for multicenter studies. |
| Databáze: | OpenAIRE |
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