An enantioselective synthesis of a MEM-protected aetheramide A derivative

Autor:	Siddhartha Akasapu, Kanury V. S. Rao, Arun K. Ghosh
Rok vydání:	2014
Předmět:	Natural product Anti hiv Stereochemistry organic chemicals Organic Chemistry Asymmetric hydrogenation Enantioselective synthesis Biochemistry Article chemistry.chemical_compound chemistry Dihydroxylation Drug Discovery Stereoselectivity Derivative (chemistry)
Zdroj:	Tetrahedron Letters. 55:5191-5194
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2014.07.077
Popis:	Aetheramides A and B are very potent anti-HIV agents. An enantioselective synthesis of a MEM-protected aetheramide A derivative is described. The synthesis was accomplished in a convergent and stereoselective manner. The key reactions involved asymmetric dihydroxylation, asymmetric allylation, asymmetric syn-aldol reactions, and asymmetric hydrogenation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6339b61fae85275cfbe331027d30d30d https://doi.org/10.1016/j.tetlet.2014.07.077 Zobrazit plný text záznamu Full Text from ScienceDirect