The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes
Autor: | He Yang, Ilan Youngster, Eric Pearlman, Nathan P. Wiederhold, Gregory A. DeIulio, Jeffrey J. Coleman, Dilay Hazal Ayhan, Kerry O’ Donnell, David C. Schwartz, Li-Jun Ma, Sergey N. Savinov, Shiguo Zhou, H. Corby Kistler, Karen Broz, Li Guo, Terrance Shea, Qiandong Zeng, Antonio Di Pietro, Yong Zhang, Martijn Rep, David Turrà, Sarah Young, Alexander J. McAdam |
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Přispěvatelé: | Zhang, Yong, Yang, He, Turra, David, Zhou, Shiguo, Ayhan, Dilay Hazal, Deiulio, Gregory A., Guo, Li, Broz, Karen, Wiederhold, Nathan, Coleman, Jeffrey J., Donnell, Kerry O’, Youngster, Ilan, Mcadam, Alexander J., Savinov, Sergey, Shea, Terrance, Young, Sarah, Zeng, Qiandong, Rep, Martijn, Pearlman, Eric, Schwartz, David C., Di Pietro, Antonio, Kistler, H. Corby, Li-Jun, Ma, Molecular Plant Pathology (SILS, FNWI) |
Rok vydání: | 2020 |
Předmět: |
Models
Molecular Fusarium Protein Conformation Medicine (miscellaneous) Opportunistic Infections Biology Genome informatics Genome Article Chromosomes General Biochemistry Genetics and Molecular Biology Fungal Proteins Structure-Activity Relationship 03 medical and health sciences Models Gene Expression Regulation Fungal Fusarium oxysporum Genetics Homologous chromosome Humans Fungal genomics Amino Acid Sequence lcsh:QH301-705.5 Gene Phylogeny 030304 developmental biology 0303 health sciences 030306 microbiology Strain (biology) Human Genome food and beverages Molecular biology.organism_classification 3. Good health Housekeeping gene Fungal lcsh:Biology (General) Gene Expression Regulation Fusariosis Pathogens Chromosomes Fungal Genome Fungal Infection General Agricultural and Biological Sciences Niche adaptation |
Zdroj: | Communications biology, vol 3, iss 1 Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020) Communications biology, 3:50. Springer Nature Communications Biology |
ISSN: | 2399-3642 |
Popis: | Fusarium oxysporum is a cross-kingdom fungal pathogen that infects plants and humans. Horizontally transferred lineage-specific (LS) chromosomes were reported to determine host-specific pathogenicity among phytopathogenic F. oxysporum. However, the existence and functional importance of LS chromosomes among human pathogenic isolates are unknown. Here we report four unique LS chromosomes in a human pathogenic strain NRRL 32931, isolated from a leukemia patient. These LS chromosomes were devoid of housekeeping genes, but were significantly enriched in genes encoding metal ion transporters and cation transporters. Homologs of NRRL 32931 LS genes, including a homolog of ceruloplasmin and the genes that contribute to the expansion of the alkaline pH-responsive transcription factor PacC/Rim1p, were also present in the genome of NRRL 47514, a strain associated with Fusarium keratitis outbreak. This study provides the first evidence, to our knowledge, for genomic compartmentalization in two human pathogenic fungal genomes and suggests an important role of LS chromosomes in niche adaptation. Zhang, Yang et al. compare a Fusarium oxysporum isolate obtained clinically to a phytopathogenic strain to examine transfer of lineage-specific chromosomes in determining host specificity. They find four unique lineage-specific chromosomes that seem to contribute to fungal adaptation to human hosts. |
Databáze: | OpenAIRE |
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