The Efficacy of Gadobenate Dimeglumine (Gd-BOPTA) at 3 Tesla in Brain Magnetic Resonance Imaging
| Autor: | Carney Jackson, Bernd J. Wintersperger, Tushar Patel, Val M. Runge, Christoph U. Herborn, Jonmenjoy Biswas, Shannon S. Baumann |
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| Rok vydání: | 2006 |
| Předmět: |
Gadolinium DTPA
Gd bopta Contrast enhancement Contrast Media Random Allocation Meglumine Organometallic Compounds Animals Medicine Radiology Nuclear Medicine and imaging Brain magnetic resonance imaging GADOBENATE DIMEGLUMINE Random allocation Gadolinium-Chelate medicine.diagnostic_test Brain Neoplasms business.industry Magnetic resonance imaging Glioma General Medicine Rat brain Magnetic Resonance Imaging Rats Inbred F344 Rats Female business Nuclear medicine |
| Zdroj: | Investigative Radiology. 41:244-248 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/01.rli.0000191332.24773.e7 |
| Popis: | The objectives of this study were to analyze the differences in contrast enhancement using gadobenate dimeglumine (Gd-BOPTA or MultiHance) at 3 T versus 1.5 T and to compare Gd-BOPTA with a standard gadolinium chelate, gadopentetate dimeglumine (Gd-DTPA or Magnevist), at 3 T in a rat glioma model.Twelve rats with surgically implanted gliomas were randomized to either comparing Gd-BOPTA at 1.5 T versus 3 T (n=7) or comparing Gd-BOPTA and Gd-DTPA at 3 T (n=5). Matched T1-weighted spin-echo techniques were used for both comparisons and the order of examinations was randomized. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and lesion enhancement (LE) were evaluated using a region-of-interest analysis. A veterinary histopathologist evaluated all brain specimens.In the evaluation of Gd-BOPTA at 3 T and 1.5 T, there were significant increases in SNR, LE, and CNR at 3 T. Average increases in brain and tumor SNR were 93% (P0.0001) and 92% (P0.0001), respectively. CNR increased by 121% (P0.0001). Comparison of Gd-BOPTA and Gd-DTPA at 3 T demonstrated significantly higher CNR and LE with Gd-BOPTA. CNR increased by 35% (P=0.002). LE increased by 44% (P=0.03).Gd-BOPTA provides significantly higher CNR at 3 T compared with 1.5 T and also demonstrates significantly higher CNR when compared with a standard Gd-chelate at 3 T. As a result of transient protein binding, Gd-BOPTA may be superior to standard gadolinium chelates in neurologic imaging at 3 T. |
| Databáze: | OpenAIRE |
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