Clinical Aggressiveness and Long-Term Outcome in Patients with Papillary Thyroid Cancer and Circulating Anti-Thyroglobulin Autoantibodies
| Autor: | Cosimo, Durante, Sara, Tognini, Teresa, Montesano, Fabio, Orlandi, Massimo, Torlontano, Efisio, Puxeddu, Marco, Attard, Giuseppe, Costante, Salvatore, Tumino, Domenico, Meringolo, Rocco, Bruno, Fabiana, Trulli, Maria, Toteda, Adriano, Redler, Giuseppe, Ronga, Sebastiano, Filetti, Fabio, Monzani, Marian Everett, Kent |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
papillary thyroid cancer
anti-thyroglobulin autoantibodies Male Pathology endocrine system diseases papillary thyroid carcinoma anti-tg antibody prognosis Endocrinology Diabetes and Metabolism medicine.medical_treatment Gastroenterology Thyroiditis Papillary thyroid cancer Endocrinology thyroid neoplasia 80 and over Young adult Child Aged 80 and over Middle Aged Diabetes and Metabolism Titer Local anti-thyroglobulin antibody Cohort Thyroidectomy Female Adult medicine.medical_specialty endocrine system Adolescent Thyroglobulin thyroid neoplasia papillary thyroid carcinoma anti-thyroglobulin antibody recurrences Young Adult Internal medicine medicine Humans Thyroid Neoplasms Aged Autoantibodies Retrospective Studies recurrences business.industry Neoplasm Recurrence Local Prognosis Retrospective cohort study Thyroid Cancer and Nodules medicine.disease Neoplasm Recurrence business |
| Popis: | Objective: The association between papillary thyroid cancer (PTC) and Hashimoto's thyroiditis is widely recognized, but less is known about the possible link between circulating anti-thyroglobulin antibody (TgAb) titers and PTC aggressiveness. To shed light on this issue, we retrospectively examined a large series of PTC patients with and without positive TgAb. Methods: Data on 220 TgAb-positive PTC patients (study cohort) were retrospectively collected in 10 hospital-based referral centers. All the patients had undergone near-total thyroidectomy with or without radioiodine remnant ablation. Tumor characteristics and long-term outcomes (follow-up range: 2.5–24.8 years) were compared with those recently reported in 1020 TgAb-negative PTC patients with similar demographic characteristics. We also assessed the impact on clinical outcome of early titer disappearance in the TgAb-positive group. Results: At baseline, the study cohort (mean age 45.9 years, range 12.5–84.1 years; 85% female) had a significantly higher prevalence of high-risk patients (6.9% vs. 3.2%, p |
| Databáze: | OpenAIRE |
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