Hafnium Oxide-Based Nanoplatform for Combined Chemoradiotherapy
| Autor: | V. N. Morozov, Evamarie Hey-Hawkins, Elena F. Krivoshapkina, Pavel V. Krivoshapkin, Anastasiia A. Sherstiuk, Anna F. Fakhardo, Sergey A. Tsymbal |
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| Rok vydání: | 2021 |
| Předmět: |
Chemistry
medicine.medical_treatment Biomedical Engineering Nanoparticle Oxides Chemoradiotherapy Polyethylene Glycols Biomaterials Radiation therapy chemistry.chemical_compound Doxorubicin Cancer cell Drug delivery medicine Cancer research Nanoparticles Combined therapy Ethylene glycol Hafnium medicine.drug |
| Zdroj: | ACS Biomaterials Science & Engineering. 7:5633-5641 |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.1c00973 |
| Popis: | Recently, the combined therapy has become one of the main approaches in cancer treatment. Combining different approaches may provide a significant outcome by triggering several death mechanisms or causing increased damage of tumor cells without hurting healthy ones. The supramolecular nanoplatform based on a high-Z metal reported here is a suitable system for the targeted delivery of chemotherapeutic compounds, imaging, and an enhanced radiotherapy outcome. HfO2 nanoparticles coated with oleic acid and a monomethoxypoly(ethylene glycol)-poly(e-caprolactone) copolymer shell (nanoplatform) are able to accumulate inside cancer cells and release doxorubicin (DOX) under specific conditions. Neither uncoated nor coated nanoparticles show any cytotoxicity in vitro. DOX loaded onto a nanoplatform demonstrates a lower IC50 value than pure DOX. X-ray irradiation of cancer cells loaded with a nanoplatform shows a higher death rate than that for cells without nanoparticles. These results provide an important foundation for the development of complex nanoscale systems for combined cancer treatment. |
| Databáze: | OpenAIRE |
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