Long-Term Follow-Up after Open Perineal Cryotherapy in Patients with Locally Confined Prostate Cancer
| Autor: | Mack D, Kunit G, Dietze O, J. Frick, Andreas Jungwirth, Miller K, Adam U |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Biopsy Urology medicine.medical_treatment Cryotherapy Adenocarcinoma Cryosurgery Prostate cancer Postoperative Complications Prostate medicine Humans Aged Transurethral resection of the prostate Prostatectomy medicine.diagnostic_test business.industry Prostatic Neoplasms Middle Aged medicine.disease Surgery Perineum Survival Rate Regimen medicine.anatomical_structure business Follow-Up Studies |
| Zdroj: | European Urology. 32:129-132 |
| ISSN: | 1873-7560 0302-2838 |
| DOI: | 10.1159/000480846 |
| Popis: | Objective: Appropriate therapies for locally confined adenocarcinoma of the prostate are available - but there is as yet no gold standard of therapy. For that reason, old therapeutic regimens are being revised. One such regimen is cryotherapy. Methods: Between 1976 and 1989, 1,250 patients were seen with newly diagnosed prostate cancer. Sixty-six patients of stages T 1c (n = 3), T 2a (n = 32), T 2b (n = 9), T 2c (n = 11), T 3a (n = 4), T 3b (n = 5) and T 3c (n = 2) were treated by open perineal cryotherapy. Mean age was 68 years. Three months after surgery, transurethral resection of the prostate and/or perineal biopsy as performed. Results: In 66% of patients with stages T 1c -T 2b and in 87% of patients with stages T 2c -T 3c , positive biopsies were obtained. To date, 28 patients have died between 3 and 16 years after cryotherapy, with a mean survival of 7.2 years. The mean follow-up period of survivers (38 patients) is 8.5 years. Complications were: stress-incontinence in 10%, impotence in 10% and temporary rectoperineal fistula in 8%. Conclusions: Cryosurgery is an effective treatment for locally confined prostate cancer. With improvement of the procedure, clinical outcome may also improve. |
| Databáze: | OpenAIRE |
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