The role of different patterns of psychomotor symptoms in major depressive episode: Pooled analysis of the BRIDGE and BRIDGE-II-MIX cohorts
| Autor: | Allan H. Young, Giulio Perugi, Jules Angst, Cecilia Mainardi, G. Maccariello, Sergey Mosolov, Margherita Barbuti, Eduard Vieta, Isabella Pacchiarotti, Norma Verdolini, Jean-Michel Azorin, Charles L. Bowden |
|---|---|
| Přispěvatelé: | University of Zurich, Vieta, Eduard |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Psychomotor agitation 610 Medicine & health Logistic regression 03 medical and health sciences 2738 Psychiatry and Mental Health 0302 clinical medicine Antimanic Agents Internal medicine Humans Medicine major depressive episode Bipolar disorder Family history Major depressive episode Psychomotor Agitation Biological Psychiatry Depression (differential diagnoses) Psychomotor learning bipolar disorder Depressive Disorder Major psychomotor retardation psychomotor agitation Psychomotor retardation business.industry Middle Aged medicine.disease Antidepressive Agents 030227 psychiatry Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Cross-Sectional Studies Logistic Models 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics Female medicine.symptom business 2803 Biological Psychiatry 030217 neurology & neurosurgery |
| Zdroj: | Barbuti, M, Mainardi, C, Pacchiarotti, I, Verdolini, N, Maccariello, G, Angst, J, Azorin, J-M, Bowden, C L, Mosolov, S, Young, A H & Vieta, E & Perugi, G 2019, ' The role of different patterns of psychomotor symptoms in major depressive episode : pooled analysis of the BRIDGE and BRIDGE-II-MIX cohorts ', Bipolar Disorders, vol. 21, no. 8, pp. 785-793 . https://doi.org/10.1111/bdi.12816 |
| DOI: | 10.5167/uzh-222901 |
| Popis: | BACKGROUND: psychomotor agitation (PA) or retardation (PR) during major depressive episodes (MDEs) have been associated with depression severity in terms of treatment-resistance and course of illness.OBJECTIVES: we investigated the possible association of psychomotor symptoms (PMSs) during a MDE with clinical features belonging to the bipolar spectrum.METHODS: the initial sample of 7689 MDE patients was divided into three subgroups based on the presence of PR, PA and non-psychomotor symptom (NPS). Univariate comparisons and multivariate logistic regression models were performed between subgroups.RESULTS: 3720 patients presented PR (48%), 1971 shown PA (26%) and 1998 had NPS (26%). In the PR and PA subgroups, the clinical characteristics related to bipolarity, along with the diagnosis of Bipolar Disorder (BD), were significantly more frequent than in the NPS subgroup. When comparing PA and PR patients, the former presented higher rates of bipolar spectrum features, such as family history of BD (OR=1.39, CI=1.20-1.61), manic/hypomanic switches with antidepressants (OR=1.28, CI=1.11-1.48), early onset of first MDE (OR=1.40, CI=1.26-1.57), atypical (OR=1.23, CI=1.07-1.42) and psychotic features (OR=2.08, CI=1.78-2.44), treatment with mood-stabilizers (OR=1.39, CI=1.24-1.55), as well as a BD diagnosis according to both the DSM-IV criteria and the bipolar specifier criteria. When logistic regression model was performed, the clinical features that significantly differentiated PA from PR were early onset of first MDE, atypical and psychotic features, treatment with mood-stabilizers and a BD diagnosis according to the bipolar specifier criteria.CONCLUSIONS: PMSs could be considered as markers of bipolarity, illness severity, and treatment complexity, particularly if PA is present. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|