Determination of thyrotropin reference values in an adult Mexican population
| Autor: | Norman S. Vega-Servín, Lidia Moreno-Castañeda, Armando Flores-Rebollar, Aída Ruiz-Juvera, Guadalupe López-Carrasco |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Thyroid Hormones endocrine system medicine.medical_specialty Pediatrics Percentile endocrine system diseases Endocrinology Diabetes and Metabolism Population Thyroid Gland Prevalence Thyrotropin Young Adult Endocrinology Reference Values Internal medicine Humans Medicine Family history education Mexico Physical Examination Autoantibodies education.field_of_study business.industry Thyroid disease Thyroid medicine.disease Healthy Volunteers Anti-thyroid autoantibodies Personnel Hospital Cross-Sectional Studies medicine.anatomical_structure Female business Iodine Hormone |
| Zdroj: | Endocrinología y Nutrición. 62:56-63 |
| ISSN: | 1575-0922 |
| DOI: | 10.1016/j.endonu.2014.10.003 |
| Popis: | Background and objective The upper limit of TSH reference level is controversial. The purpose of our study was to determine TSH reference values in a Mexican population in accordance with the National Academy of Clinical Biochemistry (NACB) criteria and in correlation with thyroid ultrasound (US) examination. Patients and methods The study was conducted in volunteers with no known thyroid disease. We recruited 482 subjects, most of them medical or administrative staff from our hospital. They answered a questionnaire on demographic data, family history, co-morbidities, and drug use. Their thyroid hormone levels and thyroid antibodies were determined, and a complete physical examination and thyroid US were performed. The population used to establish the TSH reference intervals was selected according to the NACB criteria and their normal thyroid structural and echogenic characteristics in US examination. Results Among 482 subjects (209 males) with a median age of 26 years, prevalence rates of TPOAb and TgAb were 9.3% and 10.3% respectively. Mean TSH level in the overall population was 1.90 ± 1.94, with a 97.5th percentile of 6.76 mIU/L. The reference population was limited to 282 subjects (41.5% were excluded) with a mean TSH of 1.86 ± 1.63 and a 97.5th percentile of 4.88 mIU/L. No sex difference was found (p = 0.287). Median urinary iodine level in the reference population was 267 μg/L IQR (161.3–482.5). Conclusions The TSH reference interval in the reference population was 0.71 (CI 0.65–0.77) to 4.88 mIU/L (CI 4.5–5.3); these limits may be influenced by iodine nutritional status in this population. |
| Databáze: | OpenAIRE |
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