How does mutation affect the distribution of phenotypes?
| Autor: | Katrina McGuigan, Ernest Aw |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0106 biological sciences 0301 basic medicine Aging Ontogeny Mutagenesis (molecular biology technique) Biology Phenome 010603 evolutionary biology 01 natural sciences Evolution Molecular 03 medical and health sciences Sex Factors Genetic variation Genetics Animals Swimming Zebrafish Ecology Evolution Behavior and Systematics Genetic Variation Quantitative genetics Phenotype 030104 developmental biology Mutagenesis Mutation (genetic algorithm) Trait Female General Agricultural and Biological Sciences |
| Zdroj: | Evolution. 71:2445-2456 |
| ISSN: | 1558-5646 0014-3820 |
| DOI: | 10.1111/evo.13358 |
| Popis: | The potential for mutational processes to influence patterns of neutral or adaptive phenotypic evolution is not well understood. If mutations are directionally biased, shifting trait means in a particular direction, or if mutation generates more variance in some directions of multivariate trait space than others, mutation itself might be a source of bias in phenotypic evolution. Here, we use mutagenesis to investigate the affect of mutation on trait mean and (co)variances in zebrafish, Danio rerio. Mutation altered the relationship between age and both prolonged swimming speed and body shape. These observations suggest that mutational effects on ontogeny or aging have the potential to generate variance across the phenome. Mutations had a far greater effect in males than females, although whether this is a reflection of sex-specific ontogeny or aging remains to be determined. In males, mutations generated positive covariance between swimming speed, size, and body shape suggesting the potential for mutation to affect the evolutionary covariation of these traits. Overall, our observations suggest that mutation does not generate equal variance in all directions of phenotypic space or in each sex, and that pervasive variation in ontogeny or aging within a cohort could affect the variation available to evolution. |
| Databáze: | OpenAIRE |
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