Diagnostic accuracy of contrast-enhanced FDG-PET/CT in primary staging of cutaneous malignant melanoma
| Autor: | Florian M. Vogt, Sandra J. Rosenbaum, Robert Jablonka, Gerald Antoch, Andreas Bockisch, Gerlinde Dahmen, Thomas Beyer, Patrick Veit-Haibach, Hilmar Kuehl |
|---|---|
| Přispěvatelé: | University of Zurich, Veit-Haibach, Patrick |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Skin Neoplasms Time Factors Contrast Media Diagnostic accuracy 610 Medicine & health Newly diagnosed Sensitivity and Specificity 142-005 142-005 Fluorodeoxyglucose F18 Humans Medicine 2741 Radiology Nuclear Medicine and Imaging Radiology Nuclear Medicine and imaging In patient Neoplasm Metastasis Melanoma neoplasms Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Positron emission tomography Positron-Emission Tomography Cutaneous melanoma Female Fdg pet ct Radiology Tomography Tomography X-Ray Computed business Follow-Up Studies |
| DOI: | 10.5167/uzh-155704 |
| Popis: | Purpose: To evaluate the diagnostic accuracy of contrast-enhanced FDG-PET/CT (ce-PET/CT), PET-only, and CT-only in patients with newly diagnosed and resected cutaneous malignant melanoma. Methods: A final group of 56 patients (mean age 62years, range 23-86years; 29 women, 27 men) were staged with ce-PET/CT after resection of the primary tumour. Histopathology as well as clinical follow-up (mean 780days, range 102-1,390 days) served as the standards of reference. Differences between the staging modalities were tested for statistical significance with McNemar's test. Results: All imaging procedures provided low sensitivities in the detection of lymph nodes (sensitivity N-stage: PET/CT and PET-only 38.5%; CT-only 23.1%) and distant metastases (sensitivity M-stage: PET/CT 41.7%, PET-only 33.3%, CT-only 25.0%) in initial staging after resection of the primary tumour. No statistically significant differences were detected between the imaging procedures (p > 0.05). PET/CT resulted in an alteration in further treatment in two patients compared to PET-only and in four patients compared to CT-only. Conclusion: All imaging modalities had a low sensitivity on initial staging of patients with malignant melanoma. Thus, close patient follow-up must be considered mandatory |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|