A NOVEL AMINO-ON CPG-SUPPORT FOR THE SYNTHESIS OF 3′-AMINOALKYLATED OLIGONUCLEOTIDES
| Autor: | Nicole Zien, Matthias Paul, Rubina Glare, Andreas Wolter, Michael Leuck |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Chromatography
Time Factors Chemistry Oligonucleotide Stereochemistry Oligonucleotides Temperature General Medicine MOLECULAR BIOLOGY METHODS Chromatography Ion Exchange Cross-Linking Reagents Biochemistry Combinatorial chemistry Models Chemical Oligodeoxyribonucleotides CpG site Genetics Molecular Medicine CpG Islands Oligonucleotide Probes Molecular Biology Chromatography High Pressure Liquid |
| Zdroj: | Nucleosides, Nucleotides & Nucleic Acids. 24:989-992 |
| ISSN: | 1532-2335 1525-7770 |
| DOI: | 10.1081/ncn-200059388 |
| Popis: | The synthesis of a novel amino-ON CPG support and its application in the synthesis of 3'-aminoalkylated oligonucleotides is reported. The release of oligonucleotides with free 3'-amino groups is accomplished by treatment with concentrated ammonia for 2 h at 55 degrees C. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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