Fertilization, embryonic development and pregnancy losses with intracytoplasmic sperm injection for surgically-retrieved spermatozoa

Autor:	Anthony R. Anderson, Melissa L Kyslinger, Klaus E Wiemer, Margaret L Weikert
Rok vydání:	2002
Předmět:	Male endocrine system Ejaculated spermatozoa medicine.medical_treatment Pregnancy Maintenance Intracytoplasmic sperm injection Andrology Embryonic and Fetal Development Human fertilization Pregnancy Ongoing pregnancy medicine Humans Embryo Implantation Sperm Injections Intracytoplasmic Blastocyst reproductive and urinary physiology urogenital system business.industry Embryogenesis Pregnancy Outcome Obstetrics and Gynecology Embryo medicine.disease Spermatozoa Abortion Spontaneous medicine.anatomical_structure Reproductive Medicine Oocytes Female business Developmental Biology
Zdroj:	Reproductive BioMedicine Online. 5:142-147
ISSN:	1472-6483
DOI:	10.1016/s1472-6483(10)61616-1
Popis:	Prior to the development of intracytoplasmic sperm injection (ICSI), azoospermic and severely oligozoospermic men had little to no chance of having a biological child. In this study, ICSI outcome in 454 transfers with ejaculated spermatozoa and 59 transfers with surgically retrieved spermatozoa were evaluated. Normal fertilization rate using ejaculated spermatozoa was 75% of 5995 oocytes, and 73% of 751 oocytes for surgically retrieved spermatozoa; with ongoing pregnancy rates of 53% (242/454) and 61% (36/59) respectively. Surgically retrieved spermatozoa significantly (P < 0.05) impacted 1PN oocytes (6.1%, 46/751), severely fragmented embryos (8.8%, 46/550) and incidence of pregnancy loss (11%, 4/36). When using ejaculated spermatozoa, incidence of 1PN oocytes, severely fragmented embryos and pregnancy loss was 2.9% (177/5995), 4.5% (200/4365), 2.4% (6/242) respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e04f689ebd3385e3ff6c8dae70adf4 https://doi.org/10.1016/s1472-6483(10)61616-1 Zobrazit plný text záznamu Full Text from ScienceDirect Plný text ve formátu PDF Plný text ve formátu HTML
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