Multicenter evaluation of the safety, tolerance, and efficacy of OptiMARK in magnetic resonance imaging of the brain and spine
| Autor: | William T. C. Yuh, Robert I. Grossman, Adeoye Y. Olukotun, Kenneth R. Maravilla, Matthew J. Kuhn, Donald H. Lee, Maximilian F. Reiser, H. H. Schild, Romeo Ethier |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Aged 80 and over Male medicine.medical_specialty Cross-Over Studies medicine.diagnostic_test business.industry Brain Contrast Media Gadolinium Middle Aged Magnetic Resonance Imaging Spine Double-Blind Method Anesthesia Magnetic resonance imaging of the brain medicine Organometallic Compounds Humans Radiology Nuclear Medicine and imaging Female Radiology business Aged |
| Zdroj: | Academic radiology. 5 |
| ISSN: | 1076-6332 |
| Popis: | This was a multicenter, crossover, double-blind study. Patients with known or suspected pathology and/or structural abnormality of the brain or spine were recruited from multiple study centers and randomized to receive two unique doses of OptiMARK. There were three possible pairs of doses for administration: 0.1 and 0.3 mmol/kg, 0.1 and 0.5 mmol/kg, and 0.3 and 0.5 mmol/kg. A minimum of 24 hours was allowed between doses for adequate washout of OptiMARK. Both doses Were administered within a 7-day period, and patients were not allowed to undergo intervention that would alter the pathologic process |
| Databáze: | OpenAIRE |
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