Initial Combination Therapy Compared With Monotherapy in Diabetic Hypertensive Patients

Autor: James R. Sowers, Yodit Seifu, Guido Lastra, Ricardo Rocha, Nora Crikelair, Drew Griffin Levy
Rok vydání: 2008
Předmět:
Blood Glucose
Male
medicine.medical_specialty
Combination therapy
Endocrinology
Diabetes and Metabolism
Urology
Tetrazoles
Blood Pressure
Severity of Illness Index
law.invention
Hydrochlorothiazide
Double-Blind Method
Randomized controlled trial
law
Diabetes mellitus
Internal Medicine
medicine
Humans
Hypoglycemic Agents
Diuretics
Antihypertensive Agents
Aged
Dose-Response Relationship
Drug
biology
business.industry
C-reactive protein
Valine
Middle Aged
medicine.disease
Original Papers
C-Reactive Protein
Diabetes Mellitus
Type 1
Treatment Outcome
Blood pressure
Diabetes Mellitus
Type 2
Valsartan
Tolerability
Hypertension
Physical therapy
biology.protein
Drug Therapy
Combination
Female
Cardiology and Cardiovascular Medicine
business
Angiotensin II Type 1 Receptor Blockers
Follow-Up Studies
medicine.drug
Zdroj: J Clin Hypertens (Greenwich)
ISSN: 1751-7176
1524-6175
Popis: Subgroup analyses were performed for the diabetic and nondiabetic cohorts from 3 randomized clinical trials that had evaluated the systolic blood pressure (SBP)-lowering efficacy and tolerability of an angiotensin receptor blocker, valsartan, alone or in combination with hydrochlorothiazide to determine when and how to initiate combination therapy in hypertensive patients with diabetes. Blood pressure reductions achieved with monotherapy were compared with combination therapy in the diabetic and nondiabetic cohorts. In addition, multivariate models were developed to predict the likelihood of the goal SBP of < 130 mm Hg being reached in a diabetic patient with monotherapy or combination therapy across the range of baseline SBP values. In 2 of the 3 trials, comparable reductions in SBP were seen in the diabetic and nondiabetic cohorts. In all 3 studies, however, combination therapy provided greater blood pressure-lowering efficacy than monotherapy. The probability of achieving goal SBP was greater for diabetic patients started on combination therapy compared with monotherapy.
Databáze: OpenAIRE
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