The Effect of an Iron Supplement on Lycopene Metabolism and Absorption During Digestion in Healthy Humans
| Autor: | Chureeporn Chitchumroonchokchai, Rachel E. Kopec, Béatrice Gleize, Catherine Caris-Veyrat, Jean-Paul Bernard, Sophie Morange, Patrick Borel, Marion Nowicki |
|---|---|
| Přispěvatelé: | Sécurité et Qualité des Produits d'Origine Végétale (SQPOV), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ohio State University [Columbus] (OSU), Avignon Université (AU), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), CIC - Biotherapie - Marseille, Institut National de la Santé et de la Recherche Médicale (INSERM), Avignon Université (AU)-Institut National de la Recherche Agronomique (INRA), Centre recherche en CardioVasculaire et Nutrition (C2VN), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION ) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Lipoproteins medicine.medical_treatment [SDV]Life Sciences [q-bio] Iron supplement Ferrous 03 medical and health sciences chemistry.chemical_compound Lycopene Blood plasma medicine Humans Ferrous Compounds Food science Oleoresin Carotenoid Triglycerides ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification 030109 nutrition & dietetics Middle Aged Bioavailability 030104 developmental biology Intestinal Absorption chemistry Dietary Supplements Digestion lipids (amino acids peptides and proteins) Caco-2 Cells [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Food Science Biotechnology Lipoprotein |
| Zdroj: | Molecular Nutrition and Food Research Molecular Nutrition and Food Research, 2019, 63 (22), pp.1900644. ⟨10.1002/mnfr.201900644⟩ Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2019, 63 (22), pp.1900644. ⟨10.1002/mnfr.201900644⟩ |
| ISSN: | 1613-4125 1613-4133 |
| DOI: | 10.1002/mnfr.201900644⟩ |
| Popis: | International audience; Scope: To investigate the formation and absorption of lycopene (LYC) metabolites in the human upper gastrointestinal lumen, in the absence and presence of iron. Methods: Healthy males (n = 7) consumed test meals that deliver ≈22 mg LYC + ≈0.3 mg apo-lycopenals from oleoresin without (-FeSO4) and with ferrous sulfate (160 mg, +FeSO4). Subjects were intubated with a naso-gastric/naso-duodenal tube. Digesta, blood plasma, and the triglyceride-rich lipoprotein (TRL) fractions of plasma were analyzed using LC–MS/MS, to measure LYC and apo-lycopenoids. Results: Digesta LYC concentrations increased with time (p = 1.2 × 10−7), decrease with time × iron (p = 1.1 × 10−5), and remain ≈200× higher than apo-lycopenals/lycopenone. Digesta apo-8′-, -10′-, -12′-, -14′-, -15-lycopenal, and apo-13-lycopenone concentrations increased with time (p < 0.01), apo-12′-, -14′-, -15-lycopenal, apo-13-lycopenone increase with iron (p < 0.05), and time × iron decrease apo-8′-, -10′-, -12′-, -14′-, -15-lycopenal, apo-13-lycopenone concentrations (p < 0.01). A 1.9-fold decrease in LYC TRL area-under-the-time-concentration-curve is observed after the test meal +FeSO4 versus the test meal –FeSO4 (p = 0.02). Apo-lycopenals were detected in later TRL fractions, and no apo-lycopenols or apo-lycopenoic acids were observed in any samples. Conclusions: FeSO4 reduces LYC absorption. Apo-lycopenals appear to be absorbed from foods, and not made in significant quantities during digestion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text