Physics of selective conduction and point mutation in biological ion channels
| Autor: | Carlo Guardiani, W. A. T. Gibby, Peter V. E. McClintock, Miraslau L. Barabash, Dmitry G. Luchinsky |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Models
Molecular binding sites KcsA potassium channel FOS: Physical sciences General Physics and Astronomy Ionic bonding Models Biological 01 natural sciences Molecular physics 03 medical and health sciences thermodynamics genetic models 0103 physical sciences bacterial proteins biophysical phenomena ion channels molecular models potassium channels biological models chemical models point mutation Physics - Biological Physics Ion channel 030304 developmental biology Physics 0303 health sciences Models Genetic 010304 chemical physics Point mutation Coulomb blockade Thermal conduction Models Chemical Biological Physics (physics.bio-ph) Selectivity filter Selectivity |
| Popis: | We introduce a statistical and linear response theory of selective conduction in biological ion channels with multiple binding sites and possible point mutations. We derive an effective grand-canonical ensemble and generalised Einstein relations for the selectivity filter, assuming strongly coordinated ionic motion, and allowing for ionic Coulomb blockade. The theory agrees well with data from the KcsA K$^+$ channel and a mutant. We show that the Eisenman relations for thermodynamic selectivity follow from the condition for fast conduction and find that maximum conduction requires the binding sites to be nearly identical. |
| Databáze: | OpenAIRE |
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