A biomimetic peptide recognizes and traps bacteria in vivo as human defensin-6
| Autor: | Lei Ji, Ping-Ping He, Xiao-Xue Hu, Wen Tian, Hao-Yan Zheng, Xiang-Dan Li, Kuo Zhang, Jia-Qi Fan, Hao Wang, Yu Fan, Pei-Pei Yang, Lei Wang, Zi-Ming Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
medicine.drug_class Materials Science Antibiotics Peptide 02 engineering and technology Ligands 010402 general chemistry 01 natural sciences Microbiology Defensins Mice Biomimetics Vancomycin In vivo medicine Animals Humans Peptide sequence Research Articles chemistry.chemical_classification Multidisciplinary integumentary system Bacteria biology fungi SciAdv r-articles respiratory system 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial medicine.disease Anti-Bacterial Agents 0104 chemical sciences Applied Sciences and Engineering chemistry Bacteremia 0210 nano-technology Research Article medicine.drug |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.aaz4767 |
| Popis: | A biomimetic peptide recognizes and traps bacteria in vivo as human defensin-6 for inhibiting the invasion of host cells. Using broad-spectrum antibiotics for microbial infection may cause flora disequilibrium, drug-resistance, etc., seriously threatening human health. Here, we design a human defensin-6 mimic peptide (HDMP) that inhibits bacterial invasion in vivo through mimicking the mechanisms of human defensin-6 with high efficiency and precision. The HDMP with ligand and self-assembling peptide sequence recognizes bacteria through ligand-receptor interactions and subsequently traps bacteria by an in situ adaptive self-assembly process and resulting nanofibrous networks; these trapped bacteria are unable to invade host cells. In four animal infection models, the infection rate was markedly decreased. Notably, administration of HDMP (5 mg/kg) nanoparticles increased the survival rate of mice with methicillin-resistant S. aureus bacteremia by as much as 100%, even more than that of vancomycin treatment (5 mg/kg, 83.3%)–treated group, the golden standard of antibiotics. This biomimetic peptide shows great potential as a precise and highly efficient antimicrobial agent. |
| Databáze: | OpenAIRE |
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