The Diverse Functions of MicroRNAs in Animal Development and Disease
| Autor: | Wigard P. Kloosterman, Ronald H.A. Plasterk |
|---|---|
| Přispěvatelé: | Hubrecht Institute for Developmental Biology and Stem Cell Research |
| Rok vydání: | 2006 |
| Předmět: |
Genetics
Embryology Morphogenesis Cancer Cell Biology Disease Computational biology Biology medicine.disease Models Biological General Biochemistry Genetics and Molecular Biology Animal Diseases MicroRNAs RNA interference Gene expression microRNA medicine Animals Gene silencing Signal transduction Molecular Biology Developmental Biology |
| Zdroj: | Developmental Cell, 11(4), 441-450. Cell Press |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2006.09.009 |
| Popis: | MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been implicated in tissue morphogenesis, cellular processes like apoptosis, and major signaling pathways. Emerging evidence suggests a direct link between miRNAs and disease, and miRNA expression signatures are associated with various types of cancer. In addition, the gain and loss of miRNA target sites appears to be causal to some genetic disorders. Here, we discuss the current literature on the role of miRNAs in animal development and disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|