Emilin genes are duplicated and dynamically expressed during zebrafish embryonic development
| Autor: | Paolo Bonaldo, Dino Volpin, Natascia Tiso, Francesco Argenton, Martina Milanetto, Paola Braghetta |
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| Rok vydání: | 2007 |
| Předmět: |
Embryo
Nonmammalian animal structures Danio In situ hybridization Biology Databases Genetic Gene expression Notochord medicine Animals Zebrafish Gene In Situ Hybridization Genetics Regulation of gene expression Membrane Glycoproteins fungi Embryogenesis Computational Biology Gene Expression Regulation Developmental Extracellular matrix Zebrafish Proteins biology.organism_classification Cell biology medicine.anatomical_structure Embryonic development Developmental Biology |
| Zdroj: | Developmental Dynamics. 237:222-232 |
| ISSN: | 1097-0177 1058-8388 |
| DOI: | 10.1002/dvdy.21402 |
| Popis: | Emilins are a family of extracellular matrix proteins with common structural organization and containing a characteristic N-terminal cysteine-rich domain. The prototype of this family, Emilin-1, is found in human and murine organs in association with elastic fibers, and other emilins were recently isolated in mammals. To gain insight into these proteins in lower vertebrates, we investigated the expression of emilins in the fish Danio rerio. Using sequence similarity tools, we identified eight members of this family in zebrafish. Each emilin gene has two paralogs in zebrafish, showing conserved structure with the human ortholog. In situ hybridization revealed that expression of zebrafish emilin genes is regulated in a spatiotemporal manner during embryonic development, with overlapping and site-specific patterns mostly including mesenchymal structures. Expression of certain emilin genes in peculiar areas, such as the central nervous system or the posterior notochord, suggests that they may play a role in key morphogenetic processes. Developmental Dynamics 237:222–232, 2008. © 2007 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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