A Morphologic Study of Long-term Retention of Fluorocarbon After Liquid Ventilation
| Autor: | Jerome H. Modell, C. Ian Hood |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pulmonary and Respiratory Medicine
Artificial ventilation Pathology medicine.medical_specialty Biopsy medicine.medical_treatment Respiratory System Agents Bronchi Critical Care and Intensive Care Medicine Pulmonary function testing Dogs Cell Movement Fibrosis Macrophages Alveolar Animals Medicine Longitudinal Studies Furans Lung Fluorocarbons Respiratory distress business.industry Respiratory disease Pneumonia medicine.disease Respiration Artificial Drug Residues Liquid breathing medicine.anatomical_structure Vacuoles Breathing Lymph Nodes Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Chest. 118:1436-1440 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.118.5.1436 |
| Popis: | Study objectives To determine how long perfluorinatedhydrocarbons remain in the lung after they are used for lungventilation in dogs, and to determine if residual perfluorinatedhydrocarbons cause structural alteration or an inflammatory reaction ofthe lung. Design Adult dogs were anesthetized andreceived ventilation with oxygenated perfluorinated hydrocarbon liquid.Morphologic studies of tissue from the lungs of these dogs wereperformed at intervals of a few minutes to 10 years after reconversionto breathing gas. Setting University College ofMedicine. Participants Adult mongrel and beagledogs. Interventions Anesthetized adult dogs breathedoxygenated liquid fluorocarbons for 1 h and then were reconvertedto breathing air. Three fluorocarbons, FX-80(C 8 F 16 O; 3M Company; St. Paul, MN), Caroxin-D(C 10 F 22 O 2 ; P-1D; Allied ChemicalCompany; Morristown, NJ), and Caroxin-F(C 9 F 20 O; P-12F; Allied Chemical Company), wereused. Morphologic studies of the lungs of these animals were performedimmediately after restoration of air breathing and at intervals for upto 10 years. Not all animals were studied at each time interval. Measurements and results A transient, acute inflammatoryreaction was followed by a massive influx of macrophages, which were atfirst intra-alveolar and later interstitial, especially around vesselsand bronchioles. Fluorocarbons remained in the lung in diminishingamounts for at least 5 years, as evidenced by persistent vacuolatedmacrophages in the alveoli, interstitium, and hilar lymph nodes;fluorocarbon was also detected in these tissues by chemical assays. Inno case was there fibrosis or any other structural alterationassociated with the residual fluorocarbon, which suggests that it wasinert. At 10 years, no evidence of residual fluorocarbon was seenmorphologically. |
| Databáze: | OpenAIRE |
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