Effects of nicotine on regional blood flow in the olfactory bulb in rats
| Autor: | Harumi Hotta, Sae Uchida, Kanako Shiba, Takeo Machida |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Olfactory system Nicotine medicine.medical_specialty Vasodilator Agents Central nervous system Hemodynamics Blood Pressure Nicotinic Antagonists Hexamethonium chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Pharmacology Dose-Response Relationship Drug business.industry Blood flow Olfactory Bulb Rats Olfactory bulb Blood pressure Endocrinology medicine.anatomical_structure nervous system chemistry Regional Blood Flow business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 546:148-151 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2006.06.057 |
| Popis: | Effects of nicotine on blood flow in the olfactory bulb were examined in anesthetized rats. Nicotine administered intravenously at 100 microg/kg increased regional blood flow in the olfactory bulb, irrespective of changes in systemic arterial pressure. Nicotine administered locally into the internal carotid artery at 10 microg increased blood flow, without changing arterial pressure; this response was abolished by hexamethonium. These results indicate that nicotine produces vasodilatation in the olfactory bulb via activation of nicotinic receptors located close to the olfactory bulb. Nicotine may be of therapeutic value in improving blood flow in the olfactory bulb. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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