Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass
| Autor: | Luc Barvais, Jean Louis Leclerc, Song Wan, Jean-Marie DeSmet, M Goldstein, Jean Louis Vincent |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Cardiac Catheterization medicine.medical_treatment Myocardial Infarction Myocardial Reperfusion law.invention Proinflammatory cytokine Veins Postoperative Complications law Internal medicine Catheterization Peripheral Cardiopulmonary bypass Medicine Humans Derivation Coronary Artery Bypass Lung Coronary sinus Aged Cardiopulmonary Bypass business.industry Heparin Interleukin-6 Tumor Necrosis Factor-alpha Interleukins Myocardium Interleukin-8 Pulmonary artery catheter Anticoagulants Arteries Arterial catheter Middle Aged Coronary Vessels Interleukin-10 medicine.anatomical_structure Elective Surgical Procedures Anesthesia Catheterization Swan-Ganz Cardiology Arterial blood Female Surgery Inflammation Mediators business Cardiology and Cardiovascular Medicine Artery |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 112(3):806-811 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(96)70068-5 |
| Popis: | Proinflammatory cytokines, such as tumor necrosis factor–α, interleukin-6, and interleukin-8, and antiinflammatory cytokines, such as interleukin-10, may play an important role in patient responses to cardiopulmonary bypass. We sought to define whether the myocardium and the lungs serve as important sources of these cytokines under conditions of cardiopulmonary bypass. Ten patients (age 64 ± 3 years, mean ± standard error of the mean) undergoing elective coronary artery bypass grafting were monitored with an arterial catheter, a coronary sinus catheter, and a pulmonary artery catheter. Plasma levels of tumor necrosis factor–α, interleukin-6, interleukin-8, and interleukin-10 were measured simultaneously in peripheral arterial blood, coronary sinus blood, and mixed venous blood before heparin administration, 1 minute before aortic crossclamping, 5 minutes after aortic declamping, and at 0.5, 1, 1.5 and 2 hours after aortic declamping. The durations of cardiopulmonary bypass and aortic crossclamping were 114 ± 9 and 64 ± 5 minutes, respectively. Levels of tumor necrosis factor–α and interleukin-6 were significantly higher in coronary sinus blood than in arterial blood after aortic declamping. Tumor necrosis factor–α and interleukin-6 levels were also higher in mixed venous blood than in arterial blood within 1 hour after declamping. There were no significant differences among the three sampling sites with respect to interleukin-8 and interleukin-10 levels. In one patient who had postoperative myocardial infarction, however, interleukin-8 levels were three times as high as in coronary sinus blood than in arterial blood. These data indicate that the myocardium is a major source of tumor necrosis factor–α and interleukin-6 in patients undergoing cardiopulmonary bypass. The lungs may consume rather than release proinflammatory cytokines in the early phase of reperfusion. The source under these conditions of the antiinflammatory cytokine interleukin-10 remains to be determined. (J THORAC CARDIOVASC SURG 1996;112:806-11) |
| Databáze: | OpenAIRE |
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