Alternating combination chemotherapy for stages III and IV ovarian carcinoma
| Autor: | J Kroener, Sidney L. Saltzstein, J A Koziol, J A Young, T N Campbell, A Johnson, J L Yon, William E. Lucas, Mark R. Green |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Cyclophosphamide medicine.medical_treatment Adenocarcinoma Gastroenterology Internal medicine Ovarian carcinoma Antineoplastic Combined Chemotherapy Protocols medicine Humans Aged Ovarian Neoplasms Cisplatin Chemotherapy business.industry Combination chemotherapy Middle Aged Debulking medicine.disease Combined Modality Therapy Female Methotrexate business medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 2:1317-1320 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.1984.2.12.1317 |
| Popis: | Thirty-nine previously untreated patients with stages III and IV ovarian carcinoma were treated with debulking surgery, followed by alternating combination chemotherapy with cisplatin, Adriamycin (Adria Laboratories, Columbus, Ohio), and cyclophosphamide (PAC); and hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil (HexaCAF). Of 19 patients with measureable disease at the onset of therapy, ten (53%) had at least a partial response to chemotherapy. Seven (18% of total) patients were found to be pathologically free of disease at secondlook surgery, but four patients relapsed 19 to 31 months after initiating therapy. The median progression-free survival period of all 39 patients entered into the study is 12 months, and the median crude survival is 21 months. The PAC/HexaCAF alternating combination chemotherapy regimen may be administered with moderate toxicity, but the treatment results are not superior to those reported for PAC or HexaCAF alone in advanced ovarian carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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