Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
| Autor: | Gao Ping, Wang Xiaohui, Chen Bin, Zhang Ting, Shi Mengrou, Li Xin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pentobarbital
medicine.drug_class medicine.medical_treatment Intraperitoneal injection Analgesic Chloral hydrate General anesthesia Anesthesia General Hypnotic Mice Brimonidine Tartrate Anesthesiology medicine Animals RD78.3-87.3 Dose-Response Relationship Drug business.industry Brimonidine Research Lethal dose 50 Effective dose 50 Anesthesiology and Pain Medicine Adrenergic alpha-2 receptor agonists Anesthesia Systemic administration Rabbits business medicine.drug Brimonidine tartrate |
| Zdroj: | BMC Anesthesiology, Vol 21, Iss 1, Pp 1-12 (2021) BMC Anesthesiology |
| ISSN: | 1471-2253 |
| Popis: | Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the analgesic activity of brimonidine. Methods The median effective dose (ED50) and lethal dose (LD50) of intraperitoneally injected brimonidine were determined in hypnotized mice. In addition, the LD50 of intravenously injected brimonidine, and ED50 of intravenously, intramuscularly, and intrarectally injected brimonidine in hypnotized rabbits were determined. Finally, the synergistic anesthetic effect of brimonidine and chloral hydrate was evaluated in rabbits. Results Intraperitoneal injection of 10 mg/kg brimonidine enhanced the hypnotic effect of a threshold dose of pentobarbital. Intraperitoneally injected brimonidine produced dose-related analgesic effects in mice. The ED50 of intraperitoneally administered brimonidine in hypnotized mice was 75.7 mg/kg and the LD50 was 379 mg/kg. ED50 values of intravenous, intramuscular, and intrarectal brimonidine for hypnosis in rabbits were 5.2 mg/kg, 8.8 mg/kg, and 8.7 mg/kg, respectively; the LD50 of intravenous brimonidine was 146 mg/kg. Combined intravenous administration of 0.6 mg/kg brimonidine and 0.03 g/kg chloral hydrate had a synergistic anesthetic effect. Conclusions Brimonidine elicited hypnotic and analgesic effects after systemic administration and exhibited safety. Moreover, brimonidine enhanced the effects of other types of narcotics when combined. |
| Databáze: | OpenAIRE |
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