Demonstration of Histamine Receptors on Human Platelets by Flow Cytometry
| Autor: | Torgny Hallberg, Mikael Dohlsten, Bo Baldetorp |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Chemistry Hematology Histamine H1 receptor Flow Cytometry Histamine receptor chemistry.chemical_compound Endocrinology Histamine H2 receptor Internal medicine medicine Humans Receptors Histamine Receptors Histamine H2 Platelet Receptors Histamine H1 Histamine H4 receptor Cimetidine Receptor Histamine medicine.drug |
| Zdroj: | Scandinavian Journal of Haematology. 32:113-118 |
| ISSN: | 0036-553X |
| Popis: | Fluoresceinated human albumin conjugated with histamine (FHA-HIS) has been used for the demonstration of histamine receptors on human platelets. Such receptors were demonstrated on 40-63% of peripheral blood platelets in 4 healthy donors. The binding of FHA-HIS was inhibited on 35-79% of the platelets by the histamine H1 receptor antagonists diphenhydramine and clemastine. The histamine H2 receptor antagonist cimetidine blocked the FHA-HIS binding on 14-37% of the platelets. It is concluded that histamine H1 as well as H2 receptors occur on human platelets but the receptors are not equally distributed in the platelet population. |
| Databáze: | OpenAIRE |
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