Synergistic antibacterial polyacrylonitrile/gelatin nanofibers coated with metal-organic frameworks for accelerating wound repair
| Autor: | Yi-Ning Ding, Yun-Ze Long, Zhi-Kai Cao, Jun Yang, Chun-Li Liu, Jun Zhang, Tian-Cai Sun, Seeram Ramakrishna, Xiao-Han Bai |
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| Rok vydání: | 2021 |
| Předmět: |
Male
food.ingredient Materials science Secondary growth Acrylic Resins Nanofibers Microbial Sensitivity Tests Antibacterial effect Biochemistry Gelatin Rats Sprague-Dawley chemistry.chemical_compound food Coated Materials Biocompatible X-Ray Diffraction Structural Biology Spectroscopy Fourier Transform Infrared Animals Particle Size Molecular Biology Metal-Organic Frameworks Wound Healing Doping Polyacrylonitrile Drug Synergism General Medicine Hydrogen-Ion Concentration Anti-Bacterial Agents Disease Models Animal Drug Liberation chemistry Chemical engineering Nanofiber Nanoparticles Metal-organic framework Wound healing |
| Zdroj: | International Journal of Biological Macromolecules. 189:698-704 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2021.08.175 |
| Popis: | Bacterial infections prolong the wound healing time and increase the suffering of patients, thus it is important to develop wound dressing that can inhibit bacterial infection. Herein, we use two methods including “doping method” and “secondary growth method” to prepare ZIF-8@gentamicin embedded in and coated on polyacrylonitrile/gelatin (PG) nanofibers, separately. Composite nanofibers prepared by the secondary growth method achieve higher drug loading than that of the doping method, and the release rate can be adjusted by pH. Simultaneously increasing drug loading and regulating its release rate are achieved in the secondary growth method, which cannot be achieved by the doping method. Furthermore, synergistic antibacterial property occurs in the composite nanofibers prepared by the secondary growth method, and gentamicin loaded on ZIF-8 promotes the antibacterial effect, which shows better antibacterial effect than the doping method. As a result, during the wound infection of mouse, composite nanofibers prepared by the secondary growth method exhibit a faster recovery effect than the doping method, which effectively shortened the wound healing time from 21 days to 16 days. |
| Databáze: | OpenAIRE |
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