Cladobotric Acids A−F: New Cytotoxic Polyketides from a New Zealand Cladobotryum sp
| Autor: | Nicholas J. Cummings, Gerhard Lang, Ward T. Robinson, John W. Blunt, Murray H. G. Munro, Maya I. Mitova, Anthony L. J. Cole |
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| Rok vydání: | 2005 |
| Předmět: |
Models
Molecular Antifungal Agents Magnetic Resonance Spectroscopy Stereochemistry Molecular Conformation Antineoplastic Agents Bacillus subtilis Mice Polyketide Cytotoxic T cell Animals Spectral analysis Fermentation broth Candida albicans Cytotoxicity Bacillaceae biology Leukemia P388 Chemistry Organic Chemistry General Medicine Fungi imperfecti biology.organism_classification Bacillales Anti-Bacterial Agents Biochemistry Cell culture Botrytis Bacteria New Zealand |
| Zdroj: | The Journal of Organic Chemistry. 71:492-497 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/jo051883l |
| Popis: | [reaction: see text] Cladobotric acids A-F (1-6), fungal-derived polyketides, were isolated from the fermentation broth of a New Zealand Cladobotryum species. Structures were determined by extensive spectral analysis and X-ray crystallography, and the polyketide origin of 1-6 was concluded from feeding experiments with (13)C-labeled precursors. The observed folding pattern for the polyketide chain is unusual for fungi. Cladobotric acids A-F (1-6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans. |
| Databáze: | OpenAIRE |
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