The role of dehydroepiandrosterone (DHEA) in drug-seeking behavior
| Autor: | Einav Sudai, Rachel Maayan, Iris Gispan, Abraham Weizman, Gal Yadid |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Neuroactive steroid Substance-Related Disorders Cognitive Neuroscience media_common.quotation_subject Drug-Seeking Behavior Dehydroepiandrosterone Synaptic Transmission Nicotine Behavioral Neuroscience chemistry.chemical_compound Neurotransmitter receptor Internal medicine mental disorders polycyclic compounds medicine Animals Humans Neurotransmitter media_common Neurotransmitter Agents GABAA receptor Dehydroepiandrosterone Sulfate Addiction Mental Disorders Methamphetamine Disease Models Animal Neuropsychology and Physiological Psychology Endocrinology nervous system chemistry Psychology Neuroscience hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Neuroscience and biobehavioral reviews. 35(2) |
| ISSN: | 1873-7528 |
| Popis: | Conventional substance-abuse treatments have only had limited success especially for drugs such as cocaine, methamphetamine and nicotine. Newer data have begun to shed light on the complexity of the addictive process and new treatment approaches, including interference with brain neurosteroids, to attenuate drug-seeking behavior, are in advanced stages of development. Neurosteroids are synthesized in the brain and peripheral tissues, from cholesterol or steroidal precursors imported from peripheral sources. The most abundant neurosteroids in the human body are DHEA and its sulfate ester, DHEAS. These neurosteroids can act as modulators of neurotransmitter receptors, such as γ-aminobutyric-acid-type A (GABA(A)), NMDA, and sigma-1 receptors which may contribute to apparent enduring behavioral manifestations facilitated by substances of abuse. Neurosteroid concentrations respond to environmental and behavioral circumstances, such as stress and mood, both which are involved in the progression of substance use that advance substance addiction. This article reviews the current literature pertaining to neurosteroids and substances of abuse, focusing on DHEA, and discusses its role in drug-seeking behavior as suggested by preclinical observations. |
| Databáze: | OpenAIRE |
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