High costs of infection: Alphavirus infection reduces digestive function and bone and feather growth in nestling house sparrows (Passer domesticus)
| Autor: | Ellecia L. Rainwater, Tess L. Killpack, Carol A. Fassbinder-Orth, Dylan S. Goto, Valerie I. Shearn-Bochsler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine RNA viruses Viral Diseases Ecoimmunology viruses lcsh:Medicine Pathology and Laboratory Medicine 01 natural sciences Biochemistry Ornithology Wings Medicine and Health Sciences Animal Anatomy lcsh:Science Pathogen Multidisciplinary Sparrow biology Eukaryota Brain Viral Load Lipids 3. Good health Infectious Diseases Arboviral Infections Medical Microbiology Swallows Viral Pathogens Vertebrates Viruses Host-Pathogen Interactions Anatomy Pathogens Viral load Encephalitis Sparrows Research Article Alphaviruses Zoology Animals Wild Alphavirus 010603 evolutionary biology Microbiology Virus Birds Togaviruses 03 medical and health sciences Species Specificity biology.animal Virology medicine Animals Animal Physiology Alphavirus infection Microbial Pathogens Bone Development Alphavirus Infections Bird Diseases lcsh:R Organisms Biology and Life Sciences Feathers biology.organism_classification medicine.disease Bird Physiology Gastrointestinal Tract 030104 developmental biology Animals Newborn Amniotes lcsh:Q Digestive System Viral Transmission and Infection |
| Zdroj: | PLoS ONE, Vol 13, Iss 4, p e0195467 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Increasingly, ecoimmunology studies aim to use relevant pathogen exposure to examine the impacts of infection on physiological processes in wild animals. Alphaviruses are arthropod-borne, single-stranded RNA (ssRNA) viruses ("arboviruses") responsible for millions of cases of human illnesses each year. Buggy Creek virus (BCRV) is a unique alphavirus that is transmitted by a cimicid insect, the swallow bug, and is amplified in two avian species: the house sparrow (Passer domesticus) and the cliff swallow (Petrochelidon pyrrhonota). BCRV, like many alphaviruses, exhibits age-dependent susceptibility where the young are most susceptible to developing disease and exhibit a high mortality rate. However, alphavirus disease etiology in nestling birds is unknown. In this study, we infected nestling house sparrows with Buggy Creek virus and measured virological, pathological, growth, and digestive parameters following infection. Buggy Creek virus caused severe encephalitis in all infected nestlings, and the peak viral concentration in brain tissue was over 34 times greater than any other tissue. Growth, tissue development, and digestive function were all significantly impaired during BCRV infection. However, based on histopathological analysis performed, this impairment does not appear to be the result of direct tissue damage by the virus, but likely caused by encephalitis and neuronal invasion and impairment of the central nervous system. This is the first study to examine the course of alphavirus diseases in nestling birds and these results will improve our understanding of age-dependent infections of alphaviruses in vertebrate hosts. |
| Databáze: | OpenAIRE |
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