Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells

Autor: Jung-Yu Kan, Shih-Kai Chou, Meng-Chi Yen, Ming-Feng Hou, Po-Lin Kuo, Ya-Ling Hsu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
fatty acid transport protein 4 (FATP4)
Vimentin
migration
lcsh:Chemistry
chemistry.chemical_compound
0302 clinical medicine
Cell Movement
lipid metabolism
Gene Regulatory Networks
skin and connective tissue diseases
lcsh:QH301-705.5
Spectroscopy
chemistry.chemical_classification
biology
Cell Cycle
Fatty Acids
General Medicine
Cell cycle
Fatty Acid Transport Proteins
invasion
very long-chain acyl-CoA synthetases member 4 (ACSVL4)
Computer Science Applications
Gene Expression Regulation
Neoplastic
030220 oncology & carcinogenesis
Female
Signal Transduction
Epithelial-Mesenchymal Transition
solute carrier family 27 member 4 (SLC27A4)
proliferation
Breast Neoplasms
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
Breast cancer
breast cancer
Cell Line
Tumor
fatty acid transporter
medicine
Humans
Neoplasm Invasiveness
Gene Silencing
Physical and Theoretical Chemistry
Molecular Biology
Cell Proliferation
Fatty acid metabolism
Cell growth
Organic Chemistry
Fatty acid
medicine.disease
Solute carrier family
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
Tumor progression
biology.protein
Cancer research
Zdroj: International Journal of Molecular Sciences
Volume 19
Issue 11
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3434 (2018)
ISSN: 1422-0067
DOI: 10.3390/ijms19113434
Popis: Fatty acid metabolism is important in the regulation of breast cancer progression. Some of the proteins involved in fatty acid transport have been demonstrated to promote the proliferation, migration, and invasion in breast cancer cells. Solute carrier family 27 member 4 (SLC27A4) is a fatty acid transporter protein and is related to very long chain acyl-CoA synthetase activity. In the present study, bioinformatic analysis revealed that relatively high SLC27A4 expression was observed in all subtypes of breast tumor tissues when compared to normal breast tissues. Silencing SLC27A4 expression significantly reduced uptake of free fatty acids in two breast cancer cell lines, Hs578T and MDA-MB-231. Cell growth inhibition was observed in SLC27A4-silenced Hs578T and cell cycle was arrested at G2/M. In addition, the capacity of migration and invasion decreased in both cell lines after knockdown of SLC27A4. The epithelial&ndash
mesenchymal transition signaling pathway was inhibited because protein expression of Slug, vimentin, &alpha
smooth muscle actin, and other regulators was lower than that in control cells. Taken together, our results confirm that high SLC27A4 is associated with tumor progression in breast cancer cells. It is worth investigating whether SLC27A4 serves a diagnostic marker and therapeutic target in further studies.
Databáze: OpenAIRE
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