Embryonic exposure to model naphthenic acids delays growth and hatching in the pond snail Lymnaea stagnalis
| Autor: | Lindsay Clothier, Willem C. Wildering, Dean M. Quesnel, Christina U. Johnston, Lisa M. Gieg, Petra M. Hermann, Gordon Chua |
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| Rok vydání: | 2017 |
| Předmět: |
Environmental Engineering
Health Toxicology and Mutagenesis 0208 environmental biotechnology Carboxylic Acids Zoology Lymnaea stagnalis 02 engineering and technology Snail 010501 environmental sciences 01 natural sciences Mining Alberta chemistry.chemical_compound biology.animal Naphthenic acid Animals Environmental Chemistry Oil and Gas Fields Ponds Freshwater mollusc Lymnaea 0105 earth and related environmental sciences Invertebrate EC50 biology Ecology Public Health Environmental and Occupational Health General Medicine General Chemistry biology.organism_classification Pollution 020801 environmental engineering chemistry Toxicity Water Pollutants Chemical |
| Zdroj: | Chemosphere. 168:1578-1588 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2016.11.156 |
| Popis: | Naphthenic acids (NAs), a class of structurally diverse carboxylic acids with often complex ring structures and large aliphatic tail groups, are important by-products of many petrochemical processes including the oil sands mining activity of Northern Alberta. While it is evident that NAs have both acute and chronic harmful effects on many organisms, many aspects of their toxicity remain to be clarified. Particularly, while substantive data sets have been collected on NA toxicity in aquatic prokaryote and vertebrate model systems, to date, nothing is known about the toxic effects of these compounds on the embryonic development of aquatic invertebrate taxa, including freshwater mollusks. This study examines under laboratory conditions the toxicity of NAs extracted from oil sands process water (OSPW) and the low-molecular weight model NAs cyclohexylsuccinic acid (CHSA), cyclohexanebutyric acid (CHBA), and 4-tert-butylcyclohexane carboxylic acid (4-TBCA) on embryonic development of the snail Lymnaea stagnalis, a common freshwater gastropod with a broad Palearctic distribution. Evidence is provided for concentration-dependent teratogenic effects of both OSPW-derived and model NAs with remarkably similar nominal threshold concentrations between 15 and 20 mg/L and 28d EC50 of 31 mg/L. In addition, the data provide evidence for substantial toxicokinetic differences between CHSA, CHBA and 4-TBCA. Together, our study introduces Lymnaea stagnalis embryonic development as an effective model to assay NA-toxicity and identifies molecular architecture as a potentially important toxicokinetic parameter in the toxicity of low-molecular weight NA in embryonic development of aquatic gastropods. |
| Databáze: | OpenAIRE |
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