Outcomes in relation to antithrombotic therapy among patients with atrial fibrillation after percutaneous coronary intervention
| Autor: | Jeehoon Kang, Gregory Y.H. Lip, Jiesuck Park, You Jung Choi, Kyung Woo Park, Bongseong Kim, Eue Keun Choi, Myung Jin Cha, Seil Oh, Kyungdo Han, So Ryoung Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Epidemiology Anticoagulant Therapy medicine.medical_treatment Myocardial Infarction Coronary Artery Disease 030204 cardiovascular system & hematology Antiplatelet Therapy Vascular Medicine Postoperative Complications Medical Conditions 0302 clinical medicine Risk Factors Atrial Fibrillation Antithrombotic Prevalence Medicine and Health Sciences 030212 general & internal medicine Myocardial infarction Stroke Multidisciplinary Pharmaceutics Hazard ratio Middle Aged Prognosis Oral Antiplatelet Therapy Cardiovascular Therapy Treatment Outcome Oral antiplatelet therapy Neurology Cardiology Medicine Drug Therapy Combination Female Gastrointestinal Hemorrhage Intracranial Hemorrhages Arrhythmia Research Article medicine.medical_specialty Gastrointestinal bleeding Cerebrovascular Diseases Science Hemorrhage Lower risk 03 medical and health sciences Percutaneous Coronary Intervention Signs and Symptoms Drug Therapy Internal medicine Republic of Korea medicine Humans cardiovascular diseases Anticoagulant therapy Aged Ischemic Stroke business.industry Antiplatelet therapy Anticoagulants Percutaneous coronary intervention medicine.disease Cardiovascular disease risk Atrial fibrillation Medical risk factors Medical Risk Factors Conventional PCI Clinical Medicine business Platelet Aggregation Inhibitors |
| Zdroj: | Park, J, Choi, E K, Han, K D, Kim, B, Choi, Y J, Lee, S R, Kang, J, Cha, M J, Park, K W, Oh, S & Lip, G Y H 2020, ' Outcomes in relation to antithrombotic therapy among patients with atrial fibrillation after percutaneous coronary intervention ', PLOS ONE, vol. 15, no. 10, e0240161 . https://doi.org/10.1371/journal.pone.0240161 PLoS ONE, Vol 15, Iss 10, p e0240161 (2020) PLoS ONE |
| DOI: | 10.1371/journal.pone.0240161 |
| Popis: | BackgroundsWe investigated the prognostic impact of antithrombotic regimens at 1-year after percutaneous coronary intervention (PCI) among patients with atrial fibrillation (AF).Method and resultsA total of 13,278 AF patients who underwent PCI from 2009 to 2013 were selected from Korean National Health Insurance Service database. Patients were categorized by antithrombotic regimens at 1-year after PCI: (1) OAC with or without single antiplatelet (OAC±SAPT); (2) triple therapy (TT) and (3) antiplatelets (APT) only. After propensity score matching, composite ischaemia (death, myocardial infarction, and stroke), composite bleeding (intracranial hemorrhage and gastrointestinal bleeding), and a composite clinical outcome (composite ischaemia and bleeding) were compared. Of total population, 1,100 (8.3%), 746 (5.6%), and 11,432 (86.1%) were treated with OAC±SAPT, TT, and APT only, respectively. Compared to OAC±SAPT group, the TT group had significantly higher risk of the composite clinical outcome (hazard ratio [HR] 1.46, 95% confidence interval [CI] 1.00-2.13) attributed to a higher trend in both ischaemia (HR 1.63, 95% CI 0.99-2.67) and bleeding (HR 1.22, 95% CI 0.69-2.13). The APT only group showed a higher risk of ischaemia (HR 1.85, 95% CI 1.25-2.74), despite a lower risk of bleeding (HR 0.55, 95% CI 0.32-0.94) compared to OAC±SAPT group.ConclusionsOAC±SAPT was associated with better clinical outcomes compared to TT or APT only treatments, beyond 1-year after PCI among Asians with AF. |
| Databáze: | OpenAIRE |
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