Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol
| Autor: | Michiyo Okutani, Yusuke Sato, Hajime Kitamura, Junken Aoki, Kumiko Makide |
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| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Phospholipase A Sphingosine Physiology Lysophosphatidylethanolamine Lysophospholipids Cell Biology Lipid signaling Biology Ligands Biochemistry Receptors G-Protein-Coupled chemistry.chemical_compound Receptors Lysophospholipid chemistry Lysophosphatidylserine Lysophosphatidic acid Lysophosphatidylinositol Animals Humans Protein Isoforms lipids (amino acids peptides and proteins) Signal Transduction |
| Zdroj: | Prostaglandins & Other Lipid Mediators. 89:135-139 |
| ISSN: | 1098-8823 |
| DOI: | 10.1016/j.prostaglandins.2009.04.009 |
| Popis: | It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G-protein-coupled receptors. Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo. On the other hand, other LPLs such as lysophosphatidylserine (LPS), lysophosphatidylthreonine (LPT), lysophosphatidylethanolamine (LPE), lysophosphatidylinositol (LPI) and lysophosphatidylglycerol (LPG) have been reported to show lipid mediator-like responses both in vivo (LPS and LPT) and in vitro (LPS, LPT, LPE and LPG), while very little is known about their receptor, synthetic enzyme and patho-physiological roles. In this review, we summarize the actions of these LPLs as lipid mediators including LPS, LPT, LPE and LPG. |
| Databáze: | OpenAIRE |
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