Skin autofluorescence is associated with 5-year mortality and cardiovascular events in patients with peripheral artery disease
| Autor: | Willem M. Lijfering, Nanne Kleefstra, Pieter Willem Kamphuisen, Robin P. F. Dullaart, Clark J. Zeebregts, Joop D. Lefrandt, Lisanne C. de Vos, Douwe J. Mulder, Andries J. Smit |
|---|---|
| Přispěvatelé: | Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Lifestyle Medicine (LM), Cardiovascular Centre (CVC), Man, Biomaterials and Microbes (MBM) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
ACUTE MYOCARDIAL-INFARCTION Disease peripheral artery disease Interquartile range Internal medicine medicine Clinical endpoint Outpatient clinic Myocardial infarction OXIDATIVE STRESS DEPOSITION Prospective cohort study Stroke RISK business.industry advanced glycation end products medicine.disease Surgery cardiovascular diseases MARKER Cardiology atherosclerosis Cardiology and Cardiovascular Medicine business GLYCATION END-PRODUCTS Mace |
| Zdroj: | Arteriosclerosis thrombosis and vascular biology, 34(4), 933-938. LIPPINCOTT WILLIAMS & WILKINS Arteriosclerosis, Thrombosis, and Vascular Biology, 34(4), 933-938 |
| ISSN: | 1079-5642 |
| Popis: | Objective— Advanced glycation end products play a pivotal role in atherosclerosis. Recently, we showed that tissue advanced glycation end products deposition, noninvasively assessed by skin autofluorescence (SAF), is increased in patients with peripheral artery disease. The aim of the present study was to establish whether SAF is associated with all-cause mortality and with fatal or nonfatal major adverse cardiovascular events (MACE) in patients with peripheral artery disease. Approach and Results— We performed a single-center prospective cohort study of 252 patients with peripheral artery disease (mean age, 66 ± 11 years), recruited from the outpatient clinic (October 2007 to June 2008) who were followed until June 2013. SAF was measured with the AGE Reader. The primary end point was all-cause mortality, and the secondary end point was fatal or nonfatal MACE, defined as cardiovascular death and nonfatal myocardial infarction or stroke. During a median follow-up of 5.1 (interquartile range, 5.0–5.3) years, 62 (25%) patients died. Fatal or nonfatal MACE occurred in 62 (25%) patients. A higher SAF was associated with increased risk for all-cause mortality (hazard ratio per unit increase, 2.01; 95% confidence interval, 1.40–2.88; P =0.0002) and fatal or nonfatal MACE (hazard ratio, 1.82; 95% confidence interval, 1.28–2.60; P =0.001), also after adjustment for cardiovascular risk factors and the use of lipid-lowering drugs (hazard ratio, 1.63; 95% confidence interval, 1.13–2.34; P =0.009 and hazard ratio, 1.50; 95% confidence interval, 1.04–2.17; P =0.03, for all-cause mortality and fatal and nonfatal MACE, respectively). Conclusions— SAF as a measure of advanced glycation end products deposition is independently associated with all-cause mortality and fatal or nonfatal MACE in patients with peripheral artery disease after a 5-year follow-up. |
| Databáze: | OpenAIRE |
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