CTCF Regulates Asynchronous Replication of the Imprinted H19/Igf2 Domain
| Autor: | Rosita Bergström, Joanne Whitehead, Sreenivasulu Kurukuti, Rolf Ohlsson |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
CCCTC-Binding Factor
RNA Untranslated Inheritance Patterns Biology DNA-binding protein S Phase Genomic Imprinting Mice Insulin-Like Growth Factor II Animals Epigenetics Allele Imprinting (psychology) Paternal Inheritance Molecular Biology Alleles Genetics Replication timing Binding Sites Cell Biology Chromosomes Mammalian female genital diseases and pregnancy complications DNA-Binding Proteins Mice Inbred C57BL Repressor Proteins CTCF Mutagenesis Site-Directed RNA Long Noncoding Genomic imprinting Developmental Biology |
| Zdroj: | ResearcherID |
| ISSN: | 1551-4005 1538-4101 |
| DOI: | 10.4161/cc.6.4.3854 |
| Popis: | Asynchronous replication during S phase is a universal characteristic of genomically imprinted genes. Replication timing in imprinted domains is determined epigenetically, as it is parent of origin specific, and is seen in the absence of sequence divergence between the two alleles. At the imprinted H19/Igf2 domain, the methylated paternal allele replicates early while the CTCF-bound maternal allele replicates late during S phase. CTCF regulates the allele-specific epigenetic characteristics of this domain, including methylation, transcription and chromosome conformation. Here we show that maternal, but not paternal inheritance of a mutated H19 imprinting control region, lacking functional CTCF binding sites, underlies a late to early switch in replication timing of the maternal H19/Igf2 domain. |
| Databáze: | OpenAIRE |
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