Prevalence and risk factors of having antibodies to class I and II human leukocyte antigens in older haploidentical allograft candidates

Autor:	Le-Qing Cao, Lan-Ping Xu, Kai-Yan Liu, Xiao-Dong Mo, Meng Lv, Chen-Hua Yan, Xiao-Jun Huang, Xiao-Hui Zhang, Ying-Jun Chang, Huan Chen, Wei Han, Yu-Hong Chen, Fei-Fei Tang, Yu-Qian Sun, Feng-Rong Wang
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.medical_specialty lcsh:Medicine Human leukocyte antigen Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Risk factor lcsh:Science Pregnancy Multidisciplinary biology Donor selection Umbilical Cord Blood Transplantation business.industry lcsh:R medicine.disease Transplantation Hematologic disease 030220 oncology & carcinogenesis biology.protein lcsh:Q Antibody business 030215 immunology
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
ISSN:	2045-2322
Popis:	The effect of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) has been recognized as a factor in graft failure (GF) in patients who underwent umbilical cord blood transplantation (UBT), matched unrelated donor transplantation (MUDT), or haploidentical stem cell transplantation (haplo-SCT). Presently, we know little about the prevalence of and risk factors for having anti-HLA antibodies among older transplant candidates. Therefore, we analyzed 273 older patients with hematologic disease who were waiting for haplo-SCT. Among all patients, 73 (26.7%) patients had a positive panel-reactive antibody (PRA) result for class I, 38 (13.9%) for class II, and 32 (11.7%) for both. Multivariate analysis showed that females were at a higher risk for having a PRA result for class II (P = 0.001) and for having antibodies against HLA-C and HLA-DQ. Prior pregnancy was a risk factor for having a PRA result for class I (P P = 0.014) and class II (P P = 0.042). In addition, previous total transfusions were at high risk for having higher numbers of antibodies to specific HLA loci (P = 0.005), and disease course (7.5 months or more) (P = 0.020) were related to higher MFI of PRAs for class I. Our findings indicated that female sex, prior pregnancy, platelet transfusions and disease courses are independent risk factors for older patients with hematologic disease for having anti-HLA antibodies, which could guide anti-HLA antibody monitoring and be helpful for donor selection.
Databáze:	OpenAIRE
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