Effects of gonadectomy, androgen administration and thyroidectomy on the cytology of the pituitary gland of the five-striped palm squirrel, Funambulus pennanti (Wroughton)
| Autor: | Gurmeet K. Dhaliwal, M. R. N. Prasad |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Testosterone propionate
Male endocrine system medicine.medical_specialty Pituitary gland Gonad medicine.drug_class Golgi Apparatus Rodentia Biology chemistry.chemical_compound Thyrotropic cell Internal medicine medicine Animals Testosterone Castration Acidophil cell Histocytochemistry Androgen medicine.anatomical_structure Endocrinology chemistry Propylthiouracil Pituitary Gland Thyroidectomy Female Anatomy medicine.drug |
| Zdroj: | The American journal of anatomy. 117(3) |
| ISSN: | 0002-9106 |
| Popis: | Changes in the cytology of the pituitary gland of the palm squirrel, Funambulus pennanti (Wroughton), following gonadectomy, androgen administration and propylthiouracil treatment are described. Increase in gonadotroph cell number and granulation reaches its maximum by one week after gonad ablation and is maintained at this level during the next three weeks, following which there is a gradual decline. Female squirrels show hypertrophied cells with prominent Golgi apparatus at 16 weeks after gonadectomy whereas males show similar changes four weeks after castration, changes which are still clearly noticeable at the end of 48 weeks. Castration cells or “signet-ring cells,” so characteristically seen in rats, do not occur in gonadectomized squirrels. Thyrotrophs are not affected by gonadectomy. Acidophils quickly decrease in number following gonadectomy, and are maintained at this level throughout the post-castration period. Administration of testosterone propionate to one week castrates causes degranulation in some gonadotrophs while others are coarsely granulated and deeply stained. The degranulated cells are interspersed with the other deeply stained gonadotrophs in the lateral halves of the pars anterior. Testosterone propionate administration to 12-week castrates produces no marked changes in the granule content of the gonadotrophs. Propylthiouracil treatment causes degranulation of cells located in the anteromedian zone of the pars anterior. Degranulation is partial in animals treated for 15 days but is compete after 30 days of treatment. Acidophils are partially degranulated after 30 days of propylthiouracil treatment. |
| Databáze: | OpenAIRE |
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