Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion
| Autor: | Katie Lee, Marta Thio, Megan J. Wallace, Richard Carnibella, Charles Christoph Roehr, Andreas Fouras, Marcus J. Kitchen, Stuart B. Hooper, Lauren T. Kerr, Philip DeKoninck, Arjan B. te Pas, Andreas W. Flemmer, Jaccques C Jani, James T. Pearson |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pédiatrie Diaphragmatic breathing 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Functional residual capacity Pregnancy 030225 pediatrics Internal medicine medicine Tidal Volume Animals Diaphragmatic hernia Lung Tidal volume business.industry Congenital diaphragmatic hernia respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Animals Newborn Regional Blood Flow Anesthesia Pediatrics Perinatology and Child Health Breathing Cardiology Female Rabbits business Hernias Diaphragmatic Congenital Pulmonary Ventilation Venous return curve |
| Zdroj: | Pediatric research, 82 (3 Pediatric Research, 82(3), 536-543 Pediatric Research |
| Popis: | BackgroundA congenital diaphragmatic hernia (DH) can result in severe lung hypoplasia that increases the risk of morbidity and mortality after birth; however, little is known about the cardiorespiratory transition at birth.MethodsUsing phase-contrast X-ray imaging and angiography, we examined the cardiorespiratory transition at birth in rabbit kittens with DHs. Surgery was performed on pregnant New Zealand white rabbits (n=18) at 25 days' gestation to induce a left-sided DH. Kittens were delivered at 30 days' gestation, intubated, and ventilated to achieve a tidal volume (V t) of 8 ml/kg in control and 4 ml/kg in DH kittens while they were imaged.ResultsFunctional residual capacity (FRC) recruitment and V t in the hypoplastic left lung were markedly reduced, resulting in a disproportionate distribution of FRC into the right lung. Following lung aeration, relative pulmonary blood flow (PBF) increased equally in both lungs, and the increase in pulmonary venous return was similar in both control and DH kittens.ConclusionThese findings indicate that nonuniform lung hypoplasia caused by DH alters the distribution of ventilation away from hypoplastic and into normally grown lung regions. During transition, the increase in PBF and pulmonary venous return, which is vital for maintaining cardiac output, is not affected by lung hypoplasia. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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