Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children
| Autor: | Silvia Maria Franciscato Cozzolino, Cristiane Chiantelli Claudio, Rose Vega Patin, Cecília Zanin Palchetti, Olga Maria Silverio Amancio, Fernanda Luisa Ceragioli Oliveira, Regina Célia de Menezes Succi, Aída de Fátima Thomé Barbosa Gouvêa, Camila Pugliese |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Male Erythrocytes lcsh:QR1-502 Physiology chemistry.chemical_element Nutritional Status HIV Infections Zinc Superoxide dismutase activity Biology medicine.disease_cause Antioxidants lcsh:Microbiology lcsh:Infectious and parasitic diseases Selenium Hiv infected medicine Humans lcsh:RC109-216 Child HIV and nutrition Medicine(all) Trace elements Superoxide Dismutase Micronutrient Diet Records NITRIFICAÇÃO Infectious Diseases Cross-Sectional Studies Biochemistry chemistry Dietary Reference Intake Oxidative stress Case-Control Studies Dismutase Female Copper |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Infectious Diseases, Vol 18, Iss 5, Pp 481-486 (2014) Brazilian Journal of Infectious Diseases v.18 n.5 2014 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 18, Issue: 5, Pages: 481-486, Published: SEP 2014 |
| Popis: | Objective: This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group. Methods: A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte superoxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters. Results: Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p = 0.0006) and higher copper levels (p = 0.019). No difference was found concerning superoxide dismutase activity (p > 0.05). The HIV-infected group presented a higher proportion (45.1%) of children with zinc intakes below the estimated average requirement (p = 0.014); however, no association with zinc biochemical parameters was found. Conclusion: HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress. Keywords: Antioxidants, HIV and nutrition, Oxidative stress, Trace elements |
| Databáze: | OpenAIRE |
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