Porfimer sodium-mediated photodynamic therapy in patients with head and neck squamous cell carcinoma
| Autor: | Satoru Takebayashi, Kenichi Sugiyama, Jun Okamura, Yoshinori Takizawa, Hiroyuki Mineta, Seiji Hosokawa, Goro Takahashi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Biophysics Urology Antineoplastic Agents Photodynamic therapy Dermatology medicine Humans Pharmacology (medical) Porfimer sodium Survival rate Aged Aged 80 and over Squamous Cell Carcinoma of Head and Neck business.industry Proportional hazards model Cancer Middle Aged medicine.disease Head and neck squamous-cell carcinoma Confidence interval Survival Rate medicine.anatomical_structure Photochemotherapy Oncology Dihematoporphyrin Ether Female business Respiratory tract medicine.drug |
| Zdroj: | Photodiagnosis and Photodynamic Therapy. 29:101627 |
| ISSN: | 1572-1000 |
| Popis: | Background Photodynamic therapy is a less invasive therapeutic procedure for carcinomas. The goal of this study was to evaluate the utility of Photofrin (porfimer sodium)-mediated photodynamic therapy in patients with head and neck squamous cell carcinoma. Methods Forty-two head and neck squamous cell carcinoma patients who underwent Photofrin-mediated photodynamic therapy were treated by intraoperative light activation at 630 nm via a fiber optic microlens, 48 h after injection. We evaluated the impact of age, sex, tumor stage, primary site, light dose, and cancer history on overall survival using a Cox proportional hazards model. Information on the survival status of patients was obtained after a mean follow-up period of 51 months (range, 6–180 months). Results The 5-year overall survival for all patients was 57.8 % (95 % confidence interval of the survival rate: 39.8 %–72.1 %). The complete response rate was 69.0 %, and the efficacy (complete response + partial response) was 97.6 %. Earlier tumor stage was associated with increased survival (p = 0.012). Diseases of the respiratory tract also showed significant association with survival as compared to those of the alimentary tract (p = 0.01). Conclusions Photofrin-mediated photodynamic therapy is useful for treating head and neck squamous cell carcinomas, and provides an improved quality of life in patients with recurrent or residual disease. |
| Databáze: | OpenAIRE |
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