Fibroblast growth factor 2 contributes to the effect of salidroside on dendritic and synaptic plasticity after cerebral ischemia/reperfusion injury
| Autor: | Si-Si Li, Zhen-Zhen Ma, Jian-Guang Xu, Ye-Chen Lu, Daofang Ding, Xu-Yun Hua, Xiang-Xin Xing |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging Ischemia Apoptosis Dendrite Fibroblast growth factor CREB dendrite Rats Sprague-Dawley chemistry.chemical_compound Glucosides Phenols medicine Animals Cyclic adenosine monophosphate Protein kinase A Inflammation synaptic plasticity Neuronal Plasticity biology fibroblast growth factors Infarction Middle Cerebral Artery Dendrites Cell Biology medicine.disease stroke Cyclic AMP-Dependent Protein Kinases salidroside Rats Cell biology Neuroprotective Agents medicine.anatomical_structure chemistry Reperfusion Injury Synaptic plasticity biology.protein Fibroblast Growth Factor 2 Reperfusion injury Research Paper Signal Transduction |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Ischemic stroke, a serious neurological disease, is associated with cell death, axonal and dendritic plasticity, and other activities. Anti-inflammatory, anti-apoptotic, promote dendritic and synaptic plasticity are critical therapeutic targets after ischemic stroke. Fibroblast growth factor-2 (FGF2), which is involved in the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/CAMP response element (CRE)-binding protein (CREB) pathway, has been shown to facilitate dendritic and synaptic plasticity. Salidroside (Sal) has been reported to have anti-inflammatory, anti-oxidative, and anti-apoptotic effects; however, the underlying mechanisms of Sal in promoting dendritic and synaptic plasticity remain unclear. Here, the anti-inflammatory, anti-apoptotic, dendritic and synaptic plasticity effects of Sal were investigated in vitro in PC12 cells under oxygen-glucose deprivation/reoxygenation (OGD/R) conditions and in vivo in rats with middle cerebral artery occlusion/reperfusion (MCAO/R). We investigated the role of Sal in promoting dendritic and synaptic plasticity in the ischemic penumbra and whether the FGF2-mediated cAMP/PKA/CREB pathway was involved in this process. The present study demonstrated that Sal could significantly inhibit inflammation and apoptosis, and promote dendritic and synaptic plasticity. Overall, our study suggests that Sal is an effective treatment for ischemic stroke that functions via the FGF2-mediated cAMP/PKA/CREB pathway to promote dendritic and synaptic plasticity. |
| Databáze: | OpenAIRE |
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