Clinical epidemiology of congenital heart disease in Nigerian children, 2012-2017
| Autor: | Adebowale Adeyemo, Maximilian Muenke, Paul Kruszka, Desmond Ikebudu, Akinsanya Olusegun-Joseph, Ekanem N. Ekure, Ogochukwu J. Sokunbi, Nnenna Kalu, David Bala |
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| Rok vydání: | 2018 |
| Předmět: |
Heart Defects
Congenital Male Marfan syndrome Embryology Pediatrics medicine.medical_specialty Down syndrome Adolescent Heart disease Health Toxicology and Mutagenesis Nigeria 030204 cardiovascular system & hematology Toxicology 03 medical and health sciences 0302 clinical medicine Epidemiology Conotruncal defect medicine Humans cardiovascular diseases 030212 general & internal medicine Child Tetralogy of Fallot Congenital rubella syndrome business.industry Infant Newborn Infant medicine.disease Echocardiography Child Preschool Pediatrics Perinatology and Child Health Etiology Female business Developmental Biology |
| Zdroj: | Birth Defects Research. 110:1233-1240 |
| ISSN: | 2472-1727 |
| Popis: | BACKGROUND Congenital heart diseases (CHDs) affect ~1% of newborns and are a significant cause of morbidity and mortality in children. We present the clinical epidemiology of CHD as seen in a large university medical center in Nigeria. METHODS Participants were 767 children with echocardiographically confirmed CHD seen over a 5-year period at the Lagos University Teaching Hospital, Nigeria. RESULTS Clinical presentation was often late with just over half (58.1%) presenting in infancy. The male:female distribution was 1:1. The predominant types of cardiac lesion seen were septal defects (43%), conotruncal defects (23.7%), atrioventricular septal defects (9.8%), and right ventricular outflow tract obstruction (7.3%). Cyanotic CHD was seen in 28.4% of cases and the single most common cyanotic CHD was Tetralogy of Fallot (13.4%). Children with cyanotic CHD were older (p = .002), had more severe lesions (p < .0001) and were more likely to have cardiac intervention (p < .0001). Extracardiac malformations were present in nearly one-third of the children. Syndromes associated with CHD were identified in 15.5% of the children and included Down syndrome (11.9%), congenital rubella syndrome (1.0%), and Marfan syndrome (0.7%). CONCLUSIONS This study is a large case series of CHD from a single site in sub-Saharan Africa utilizing clinical, epidemiological, and developmental considerations. It provides a rich and up-to-date description of the clinical epidemiology of CHD in Nigerian children while yielding data that could be useful for designing genetic, molecular, and biomarker studies. |
| Databáze: | OpenAIRE |
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