New ent-Kaurane and cleistanthane diterpenoids with potential cytotoxicity from Phyllanthus acidus (L.) Skeels

Autor:	Ying, Xin, Jia, Xu, Jun-Jiang, Lv, Hong-Tao, Zhu, Dong, Wang, Chong-Ren, Yang, Ying-Jun, Zhang
Rok vydání:	2022
Předmět:	Pharmacology Magnetic Resonance Spectroscopy Molecular Structure Plant Stems Plant Extracts General Medicine Plant Roots Inhibitory Concentration 50 Phyllanthus Alkaloids Cell Line Tumor Drug Discovery Humans Diterpenes Diterpenes Kaurane
Zdroj:	Fitoterapia. 157:105133
ISSN:	0367-326X
DOI:	10.1016/j.fitote.2022.105133
Popis:	Six diterpenoids including three ent-kauranes (1-2, 4) and three cleistanthanes (3, 5-6) were isolated from the roots and stems of Phyllanthus acidus (L.) Skeels. Of them, (16S)-ent-16,17,18-tri-hydroxy-19-nor-kaur-4-en-3-one (1), phyllanthone A (2), and 6-hydroxycleistanthol (3) are new compounds, while the ent-kaurane diterpenoids were reported from the titled plant for the first time. Their structures were elucidated on the basis of the extensive spectroscopic analyses. Compounds 2 and 4-6 displayed cytotoxic potential with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618f9d28acf416e95a069e7d25590893 https://doi.org/10.1016/j.fitote.2022.105133 Zobrazit plný text záznamu Full Text from ScienceDirect