Liprins in oncogenic signaling and cancer cell adhesion
| Autor: | Ivan de Curtis, Outi Monni, Henna Pehkonen |
|---|---|
| Přispěvatelé: | Pehkonen, H, de Curtis, I, Monni, O. |
| Rok vydání: | 2021 |
| Předmět: |
Scaffold protein
Cancer Research Review Article Protein tyrosine phosphatase Biology Extracellular matrix 03 medical and health sciences 0302 clinical medicine Nuclear Matrix-Associated Proteins Neoplasms Biomarkers Tumor Cell Adhesion Genetics medicine Humans Cell adhesion Molecular Biology 030304 developmental biology 0303 health sciences Cancer Oncogenes medicine.disease Review article Gene Expression Regulation Neoplastic Focal adhesion Tumor progression Multigene Family 030220 oncology & carcinogenesis Cancer cell Disease Progression Neuroscience Signal Transduction |
| Zdroj: | Oncogene |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/s41388-021-02048-1 |
| Popis: | Liprins are a multifunctional family of scaffold proteins, identified by their involvement in several important neuronal functions related to signaling and organization of synaptic structures. More recently, the knowledge on the liprin family has expanded from neuronal functions to processes relevant to cancer progression, including cell adhesion, cell motility, cancer cell invasion, and signaling. These proteins consist of regions, which by prediction are intrinsically disordered, and may be involved in the assembly of supramolecular structures relevant for their functions. This review summarizes the current understanding of the functions of liprins in different cellular processes, with special emphasis on liprins in tumor progression. The available data indicate that liprins may be potential biomarkers for cancer progression and may have therapeutic importance. |
| Databáze: | OpenAIRE |
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